Technology Process of 1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol
There total 10 articles about 1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride; trifluoroacetic acid;
In
acetic acid;
- Guidance literature:
-
sodium cyanoborohydride; 1-(1-Benzyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol;
With
sodium cyanoborohydride;
In
methanol; acetic acid;
for 3.5h;
With
sodium cyanoborohydride; trifluoroacetic acid;
for 16.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 77 percent / NaOH; TBAHS; KI / CH2Cl2 / Heating
2.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
2.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
3.1: NaBH3CN / methanol; acetic acid / 3.5 h
3.2: 82 percent / NaBH3CN; TFA / 16.5 h
With
sodium hydroxide; n-butyllithium; tetra(n-butyl)ammonium hydrogensulfate; sodium cyanoborohydride; potassium iodide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; acetic acid;
