Ethanol, 2-[methyl(4-methylphenyl)amino]-

Base Information

• Chemical Name: Ethanol, 2-[methyl(4-methylphenyl)amino]-
• CAS No.: 2842-44-6
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2921499090
• European Community (EC) Number: 220-638-5
• UNII: 982J448EHD
• DSSTox Substance ID: DTXSID2062666
• Nikkaji Number: J306.771H
• Wikidata: Q27272072
• Mol file: 2842-44-6.mol

Synonyms:2842-44-6;2-(Methyl(p-tolyl)amino)ethanol;Ethanol, 2-[methyl(4-methylphenyl)amino]-;Hydroxyethyl methyltolylamine;N-(2-hydroxyethyl)-n-methyl-4-toluidine;2-(N,4-dimethylanilino)ethanol;EINECS 220-638-5;UNII-982J448EHD;Ethanol, 2-(methyl(4-methylphenyl)amino)-;2-(N-Methyl-p-toluidino)ethanol;982J448EHD;N-methyl-N-(2-hydroxyethyl)-p-toluidine;N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE pound MHPT pound(c);2-[methyl(4-methylphenyl)amino]ethanol;2-(methyl-p-tolylamino)ethanol;FIRSTCURE MHPT;SCHEMBL194538;DTXSID2062666;CAA84244;N-Methyl-N-Hydroxyethyl-4-Toluidine;AKOS011258348;SB84210;AS-75666;N-(2-hydroxyethyl)-N-methyl-p-toluidine;HYDROXYETHYL METHYLTOLYLAMINE [INCI];2-(N-METHYL-N-4-TOLYLAMINO)ETHANOL;ETHANOL, 2-(N-METHYL-P-TOLUIDINO)-;FT-0691516;3,5-DI-O-ACETYL-5-FLUORO-2-DEOXYURIDINE;A819445;Q27272072

Chemical Property of Ethanol, 2-[methyl(4-methylphenyl)amino]-

Chemical Property:

• Vapor Pressure: 0.00058mmHg at 25°C
• Boiling Point: 298.1°Cat760mmHg
• PKA: 14.69±0.10(Predicted)
• Flash Point: 148.8°C
• PSA: 23.47000
• Density: 1.047g/cm³
• LogP: 1.42350
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 119

Purity/Quality:

99%min ^*data from raw suppliers

2-(Methyl(p-tolyl)amino)ethanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N(C)CCO
• Uses: N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE is an amine organic compound, which can be used as intermediate in organic synthesis.

Technology Process of Ethanol, 2-[methyl(4-methylphenyl)amino]-

There total 10 articles about Ethanol, 2-[methyl(4-methylphenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-methyl-p-toluidine (623-08-5) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-(methyl(p-tolyl)amino)ethan-1-ol (2842-44-6)

Guidance literature:

With N-methyl-1-(thiophen-2-yl)methanamine; tris(triphenylphosphine)ruthenium(II) chloride; 1,1'-bis(dicyclohexylphosphinocyclopentadienyl)iron; potassium tert-butylate; In 1,4-dioxane; at 150 ℃; for 20h;

DOI:10.1002/cssc.201903151

Reference yield: 82.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-tolyl iodide (624-31-7) → 2-(methyl(p-tolyl)amino)ethan-1-ol (2842-44-6)

Guidance literature:

With copper(l) iodide; sodium hydroxide; In water; dimethyl sulfoxide; at 90 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.201403917

Reference yield: 75.0%

D-Xylose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2) + N-methyl-p-toluidine (623-08-5) → 2-(methyl(p-tolyl)amino)ethan-1-ol (2842-44-6)

Guidance literature:

With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 16h; chemoselective reaction; Inert atmosphere; Glovebox;

DOI:10.1039/c9gc01195a

upstream raw materials:

N-(4-methylphenyl)-N-methylglycine ethyl ester

(2-hydroxyethyl)(methyl)amine

4-tolyl iodide

D-Xylose

Downstream raw materials:

N-(2-(benzyloxy)ethyl)-N-methyl-p-toluidine

Refernces

• 1、 Xin, Zhuo,Jia, Le,Huang, Yuxing,Du, Chen-Xia,Li, Yuehui. "Ru-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol". . p. 2007 - 2011. Retrieved 2020/03/19.
• 2、 Hurst, Timothy E.,Gorman, Ryan M.,Drouhin, Pauline,Perry, Alexis,Taylor, Richard J. K.. "A Direct C-H/Ar-H Coupling Approach to Oxindoles, Thio-oxindoles, 3,4-Dihydro-1 H-quinolin-2-ones, and 1,2,3,4-Tetrahydroquinolines". supporting information. p. 14063 - 14073. Retrieved 2016/02/18.