Technology Process of Benzotript
There total 4 articles about Benzotript which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chloro-benzoyl chloride; L-Tryptophan;
With
sodium hydroxide;
In
water;
at 20 ℃;
for 3h;
With
hydrogenchloride;
In
water;
pH=1 - 2;
DOI:10.1039/c3ob40215k
- Guidance literature:
-
Nα-Fmoc-Nim-tert-butyloxycarbonyl-L-tryptophan 4-hydroxymethylphenoxy resin;
With
piperidine;
In
N,N-dimethyl-formamide;
at 20 ℃;
para-chlorobenzoic acid;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
With
methoxybenzene; trifluoroacetic acid;
at 20 ℃;
for 1h;
DOI:10.1016/j.bmcl.2004.02.046
