Premazepam

Base Information

• Chemical Name: Premazepam
• CAS No.: 57435-86-6
• Molecular Formula: C15H15 N3 O
• Molecular Weight: 253.304
• NSC Number: 290940
• UNII: OI7443PDLB
• DSSTox Substance ID: DTXSID60206026
• Nikkaji Number: J128.618H
• Wikipedia: Premazepam
• Wikidata: Q7240235
• NCI Thesaurus Code: C66465
• ChEMBL ID: CHEMBL2104741
• Mol file: 57435-86-6.mol

Synonyms:3,7-dihydro-5-phenyl-6,7-dimethylpyrrole(3,4-e)(1,4)diazepin-2-(1H)-one;premazepam

Chemical Property of Premazepam

Chemical Property:

• Vapor Pressure: 2.34E-08mmHg at 25°C
• Refractive Index: 1.65
• Boiling Point: 451.9°C at 760 mmHg
• Flash Point: 227.1°C
• PSA: 46.39000
• Density: 1.23g/cm³
• LogP: 1.69660
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 253.121512110
• Heavy Atom Count: 19
• Complexity: 387

Purity/Quality:

99% ^*data from raw suppliers

6,7-DIMETHYL-5-PHENYL-1,3-DIHYDROPYRROLO[3,4-F][1,4]DIAZEPIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CN1C)NC(=O)CN=C2C3=CC=CC=C3

Technology Process of Premazepam

There total 1 articles about Premazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Premazepam (57435-86-6)

Guidance literature:

entspr. Phthalimidoacetamid (IV), Hydrazin;

Reference yield:

Premazepam (57435-86-6) → 8-bromo-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one (84829-73-2)

Guidance literature:

With bromine; sodium hydrogencarbonate; In methanol;

Reference yield:

Premazepam (57435-86-6) → 8-chloro-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one (84829-74-3)

Guidance literature:

With sulfuryl dichloride; sodium hydrogencarbonate; In dichloromethane;

Downstream raw materials:

8-bromo-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

8-chloro-3,7-dihydro-6,7-dimethyl-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

3,7-dihydro-6,7-dimethyl-8-nitro-5-phenylpyrrolo[3,4-e][1,4]diazepin-2(1H)-one

Refernces