Multi-step reaction with 7 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0 °C
2: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 140 °C / Sealed tube
3: tetrakis(triphenylphosphine) palladium(0); potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); caesium carbonate; potassium fluoride dihydrate / water; benzene; ethanol / 0.5 h / 85 °C / Microwave irradiation
5: trifluoroacetic acid / dichloromethane / 20 °C
6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 20 °C
7: hydrogen; palladium 10% on activated carbon; hydrogen bromide / methanol / 6 h / 3225.32 Torr
With
tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate; palladium 10% on activated carbon; ammonium acetate; hydrogen bromide; hydrogen; potassium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; benzene;