Technology Process of N-(4-iodobenzyl)hydroxylamine
There total 3 articles about N-(4-iodobenzyl)hydroxylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
p-(iodophenyl)carboxaldehyde;
With
potassium hydroxide; hydroxylamine hydrochloride;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 2h;
pH=9;
With
hydrogenchloride; sodium cyanoborohydride;
In
tetrahydrofuran; methanol; water;
for 16h;
pH=2;
- Guidance literature:
-
p-(iodophenyl)carboxaldehyde;
With
potassium hydroxide; hydroxylamine hydrochloride;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 2h;
pH=9;
sodium cyanoborohydride;
With
hydrogenchloride; methyl orange;
In
tetrahydrofuran; methanol; water;
for 16h;
pH=2 - 3;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: PDC / CH2Cl2 / 20 °C
2: aq. NH2OH; NaCNBH3 / tetrahydrofuran; methanol / 20 °C
With
dipyridinium dichromate; hydroxylamine; sodium cyanoborohydride;
In
tetrahydrofuran; methanol; dichloromethane;
1: Oxidation / 2: reductive hydroxyamination;
DOI:10.1021/ja992144n
