(S)-1-(furan-3-yl)ethan-1-ol

Base Information

• Chemical Name: (S)-1-(furan-3-yl)ethan-1-ol
• CAS No.: 1207204-70-3
• Molecular Formula: C₆H₈O₂
• Molecular Weight: 112.128
• Mol file: 1207204-70-3.mol

Synonyms:(S)-1-(furan-3-yl)ethan-1-ol

Chemical Property of (S)-1-(furan-3-yl)ethan-1-ol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(furan-3-yl)ethan-1-ol

There total 3 articles about (S)-1-(furan-3-yl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3'-furyl)-ethanol (13129-26-5) → 3-acetylfuran (14313-09-8) + (S)-1-(furan-3-yl)ethan-1-ol (1207204-70-3)

Guidance literature:

With oxygen; (-)-sparteine; In toluene; at 80 ℃; for 120h; under 760.051 Torr; optical yield given as %ee; Molecular sieve;

DOI:10.1002/chem.200902172

Reference yield:

furan-3-carboxaldehyde (498-60-2) + dimethyl zinc(II) (544-97-8) → (S)-1-(furan-3-yl)ethan-1-ol (1207204-70-3) + (R)-1-(furan-3-yl)ethanol (13129-26-5,87939-62-6)

Guidance literature:

With 2-exo-morpholinoisobornane-10-thiol; In hexane; at 20 ℃; for 48h; Overall yield = 82 %; Optical yield = 83 %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/asia.201200676

Reference yield:

3-acetylfuran (14313-09-8) → (S)-1-(furan-3-yl)ethan-1-ol (1207204-70-3) + (R)-1-(furan-3-yl)ethanol (13129-26-5,87939-62-6)

Guidance literature:

With C₄₀H₅₈Cl₂FeN₄O₆P₂; potassium tert-butylate; isopropyl alcohol; at 22 - 24 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c0cc00508h

upstream raw materials:

1-(3'-furyl)-ethanol

3-acetylfuran

furan-3-carboxaldehyde

dimethyl zinc(II)

Downstream raw materials:

(-)-α-(2-Furyl)ethyl acetate

Refernces

• 1、 Wu, Hsyueh-Liang,Wu, Ping-Yu,Cheng, Ying-Ni,Uang, Biing-Jiun. "Enantioselective addition of organozinc reagents to carbonyl compounds catalyzed by a camphor derived chiral γ-amino thiol ligand". . p. 2656 - 2665. Retrieved 2016/05/10.
• 2、 Naik, Anu,Maji, Tapan,Reiser, Oliver. "Iron(ii)-bis(isonitrile) complexes: Novel catalysts in asymmetric transfer hydrogenations of aromatic and heteroaromatic ketones". supporting information; experimental part. p. 4475 - 4477. Retrieved 2010/11/03.