benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester

Base Information

• Chemical Name: benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester
• CAS No.: 440104-25-6
• Molecular Formula: C₄₉H₇₈O₁₀
• Molecular Weight: 827.152
• Mol file: 440104-25-6.mol

Synonyms:benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester

Chemical Property of benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester

There total 57 articles about benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[1S,1(2S,5S,2'R,5'S,5'(1R)),2S,3R,4R,5E,8R,10R,14S,16S,18S]-benzoic acid 1-[5'-(1-TBDMS-ethyl)-2,5'-dimethyl-octahydro[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-3-triisopropylsilyloxy-eicos-5-enyl ester (440104-06-3) → benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester (440104-25-6)

Guidance literature:

With hydrogen fluoride; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/ol025872f

Reference yield:

3-(6-benzenesulfonyl-4-methyl-hex-3-enyl)-3-methyl-oxiran-2-ylmethanol → benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester (440104-25-6)

Guidance literature:

Multi-step reaction with 21 steps

1.1: 95 percent / pyridine / CH₂Cl₂ / 48 h / -10 °C

2.1: perchloric acid / tetrahydrofuran; H₂O / 2 h / Heating

2.2: 67 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 °C

3.1: vanadil acetylacetonate; t-butyl hydroperoxide; pyridinium para-toluenesulfonate / 4 Angstroem molecular sieve / various solvent(s); CH₂Cl₂; decane / 29 h / 20 °C

4.1: sodium iodide; 18-c-6 / butan-2-one / Heating

4.2: 81 percent / tributyltin hydride; AIBN / toluene / 3 h / Heating

5.1: 93 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

6.1: n-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: tetrahydrofuran; hexane / 0.5 h

7.1: N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 2 h / 20 °C

8.1: 673 mg / samarium diiodide / ethanol; tetrahydrofuran / 0.5 h / -78 °C

9.1: 86 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H₂O; CH₂Cl₂ / 1 h / 0 °C

10.1: 90 percent / samarium diiodide / tetrahydrofuran / 0.5 h / 0 °C

11.1: 4-dimethylaminopyridine / CH₂Cl₂

12.1: HCl / tetrahydrofuran / 5 h / 0 °C

13.1: 264 mg / sodium hydride / tetrahydrofuran / 0.33 h / 50 °C

14.1: 96 percent / Pd(OH)2 / ethanol; cyclohexane / 12 h / Heating

15.1: 91 percent / N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 0.5 h / 20 °C

16.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h

16.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C

17.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H₂O; CH₂Cl₂ / 2 h / 0 °C

18.1: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 0.92 h / -78 °C

19.1: dibutylboron triflate; diisopropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

19.2: CH₂Cl₂ / 3 h / -78 - 20 °C

20.1: 12 mg / pyridine; chromium trioxide / CH₂Cl₂ / 0.33 h / 20 °C

21.1: 85 percent / HF / H₂O; acetonitrile / 3 h / 20 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; tert.-butylhydroperoxide; dmap; n-butyllithium; perchloric acid; samarium diiodide; oxalyl dichloride; bis(acetylacetonate)oxovanadium; 18-crown-6 ether; di-n-butylboryl trifluoromethanesulfonate; hydrogen fluoride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; palladium dihydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; In tetrahydrofuran; decane; ethanol; hexane; dichloromethane; cyclohexane; water; toluene; acetonitrile; butanone; 10.1: Tishchenko reaction / 16.1: Julia reaction / 18.1: Swern oxidation / 20.1: Collins oxidation;

DOI:10.1021/ol025872f

Reference yield:

[2E,6E]-9-benzenesulfonyl-3,7-dimethyl-nona-2,6-dien-1-ol (440104-18-7) → benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester (440104-25-6)

Guidance literature:

Multi-step reaction with 22 steps

1.1: (+)-diisopropyl tartrate; titanium isopropoxide; tert-butyl hydroperoxide / CH₂Cl₂; decane / -20 °C

2.1: 95 percent / pyridine / CH₂Cl₂ / 48 h / -10 °C

3.1: perchloric acid / tetrahydrofuran; H₂O / 2 h / Heating

3.2: 67 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 °C

4.1: vanadil acetylacetonate; t-butyl hydroperoxide; pyridinium para-toluenesulfonate / 4 Angstroem molecular sieve / various solvent(s); CH₂Cl₂; decane / 29 h / 20 °C

5.1: sodium iodide; 18-c-6 / butan-2-one / Heating

5.2: 81 percent / tributyltin hydride; AIBN / toluene / 3 h / Heating

6.1: 93 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

7.1: n-butyl lithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

7.2: tetrahydrofuran; hexane / 0.5 h

8.1: N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 2 h / 20 °C

9.1: 673 mg / samarium diiodide / ethanol; tetrahydrofuran / 0.5 h / -78 °C

10.1: 86 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H₂O; CH₂Cl₂ / 1 h / 0 °C

11.1: 90 percent / samarium diiodide / tetrahydrofuran / 0.5 h / 0 °C

12.1: 4-dimethylaminopyridine / CH₂Cl₂

13.1: HCl / tetrahydrofuran / 5 h / 0 °C

14.1: 264 mg / sodium hydride / tetrahydrofuran / 0.33 h / 50 °C

15.1: 96 percent / Pd(OH)2 / ethanol; cyclohexane / 12 h / Heating

16.1: 91 percent / N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 0.5 h / 20 °C

17.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / 0.5 h

17.2: 85 percent / tetrahydrofuran; toluene / -78 - 20 °C

18.1: 97 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / H₂O; CH₂Cl₂ / 2 h / 0 °C

19.1: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 0.92 h / -78 °C

20.1: dibutylboron triflate; diisopropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

20.2: CH₂Cl₂ / 3 h / -78 - 20 °C

21.1: 12 mg / pyridine; chromium trioxide / CH₂Cl₂ / 0.33 h / 20 °C

22.1: 85 percent / HF / H₂O; acetonitrile / 3 h / 20 °C

With pyridine; chromium(VI) oxide; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; n-butyllithium; perchloric acid; samarium diiodide; oxalyl dichloride; bis(acetylacetonate)oxovanadium; L-(+)-diisopropyl tartrate; 18-crown-6 ether; di-n-butylboryl trifluoromethanesulfonate; hydrogen fluoride; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; palladium dihydroxide; tetrapropylammonium perruthennate; 4 A molecular sieve; In tetrahydrofuran; decane; ethanol; hexane; dichloromethane; cyclohexane; water; toluene; acetonitrile; butanone; 11.1: Tishchenko reaction / 17.1: Julia reaction / 19.1: Swern oxidation / 21.1: Collins oxidation;

DOI:10.1021/ol025872f

upstream raw materials:

[1S,1(2S,5S,2'R,5'S,5'(1R)),2S,3R,4R,5E,8R,10R,14S,16S,18S]-benzoic acid 1-[5'-(1-TBDMS-ethyl)-2,5'-dimethyl-octahydro[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-3-triisopropylsilyloxy-eicos-5-enyl ester

[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexanal

[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexanenitrile

[3S,5R]-6-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Downstream raw materials:

ionomycin

Refernces