2,3-Epoxypropyl propionate

Base Information

• Chemical Name: 2,3-Epoxypropyl propionate
• CAS No.: 37111-25-4
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Hs Code.: 2915509000
• European Community (EC) Number: 253-354-5
• DSSTox Substance ID: DTXSID30958282
• Nikkaji Number: J195.916F
• Mol file: 37111-25-4.mol

Synonyms:2,3-Epoxypropyl propionate;37111-25-4;EINECS 253-354-5;glycidyl propionate;Oxiranemethanol propanoate;SCHEMBL93275;(Oxiran-2-yl)methyl propanoate;DTXSID30958282;QNAJAJLBHMMOJB-UHFFFAOYSA-N

Chemical Property of 2,3-Epoxypropyl propionate

Chemical Property:

• Vapor Pressure: 1.61mmHg at 25°C
• Boiling Point: 168.6°Cat760mmHg
• Flash Point: 76.9°C
• PSA: 38.83000
• Density: 1.099g/cm³
• LogP: 0.33840
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 130.062994177
• Heavy Atom Count: 9
• Complexity: 111

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OCC1CO1

Technology Process of 2,3-Epoxypropyl propionate

There total 5 articles about 2,3-Epoxypropyl propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

sodium proprionate (137-40-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → oxiran-2-ylmethyl propionate (37111-25-4)

Guidance literature:

With 15-crown-5; In acetonitrile; for 13h; Ambient temperature;

DOI:10.1080/00397919908086413

Reference yield: 65.0%

glycidyl acrylate (106-90-1,130232-99-4,130233-00-0) → oxiran-2-ylmethyl propionate (37111-25-4)

Guidance literature:

With methanol; magnesium; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96709-1

Reference yield: 53.0%

oxiranyl-methanol (556-52-5) + propionyl chloride (79-03-8) → oxiran-2-ylmethyl propionate (37111-25-4)

Guidance literature:

With triethylamine; In toluene; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1039/C8CC06503A

upstream raw materials:

glycidyl acrylate

oxiranyl-methanol

propionyl chloride

sodium proprionate

Downstream raw materials:

2-oxopropyl propionate

3-[4-(2-Benzyloxy-4-ethylphenoxy)-3-fluorophenyl]-5-hydroxymethyloxazolidin-2-one

Refernces

• 1、 Nair, Ranjeet V.,Patil, Prashant N.,Salunkhe, Manikrao M.. "Novel synthesis and enzymatic resolution of (±)-2,3-epoxy propyl esters". . p. 2559 - 2566. Retrieved 2007/10/03.
• 2、 Macchia, B.,Balsamo, A.,Lapucci, A.,Macchia, F.,Martinelli, A.,et al.. "Role of the (Acyloxy)methyl Moiety in Eliciting the Adrenergic β-Blocking Activity of 3-(Acyloxy)propanolamines". . p. 616 - 622. Retrieved 2007/10/02.