Technology Process of Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis-
There total 10 articles about Propanamide, N-(3,4-dichlorophenyl)-N-(2-(dimethylamino)cyclopentyl)-, cis- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: concd. HCl / 168 h / Heating
2: 72 h / Heating
3: 85percent aq. ethanolic KOH / 3 h / Ambient temperature
4: CrO3, aq. H2SO4 / acetone / 0.5 h / Ambient temperature
5: 4.2 g / dimethylamine hydrochloride, NaCNBH3 / methanol / 192 h / Ambient temperature
With
chromium(VI) oxide; hydrogenchloride; potassium hydroxide; sulfuric acid; N,N-dimethylammonium chloride; sodium cyanoborohydride;
In
methanol; acetone;
DOI:10.1021/jm00142a020
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / H2O
2: 1.) NaH / 1.) THF, reflux, 1 h
3: 2.) 20percent NaOH / 1.) reflux, 17 h, 2.) 1 h
4: Heating
With
sodium hydroxide; sodium hydride;
In
water;
DOI:10.1021/jm00142a020
- Guidance literature:
-
Multi-step reaction with 2 steps
1: CrO3, aq. H2SO4 / acetone / 0.5 h / Ambient temperature
2: 4.2 g / dimethylamine hydrochloride, NaCNBH3 / methanol / 192 h / Ambient temperature
With
chromium(VI) oxide; sulfuric acid; N,N-dimethylammonium chloride; sodium cyanoborohydride;
In
methanol; acetone;
DOI:10.1021/jm00142a020