N-Phenyl-4-piperidinecarboxamide hydrochloride

Base Information

• Chemical Name: N-Phenyl-4-piperidinecarboxamide hydrochloride
• CAS No.: 73415-85-7
• Molecular Formula: C12H16 N2 O
• Molecular Weight: 204.272
• Hs Code.: 2933399090
• European Community (EC) Number: 664-222-5
• Mol file: 73415-85-7.mol

Synonyms:N-PHENYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE;73415-54-0;N-phenylpiperidine-4-carboxamide hydrochloride;N-phenylpiperidine-4-carboxamide;hydrochloride;N-Phenyl-4-piperidinecarboxamide, HCl;N-PHENYL-4-PIPERIDINECARBOXAMIDEHYDROCHLORIDE;SCHEMBL8508299;KUC112946N;MFCD07324911;n-phenyl-4-piperidinecarboxamide HCl;AKOS008048929;SB44141;KSC-334-013-;EN300-13895;G23324;A866093;SR-01000072441;J-523758;SR-01000072441-1;Z94601531

Chemical Property of N-Phenyl-4-piperidinecarboxamide hydrochloride

Chemical Property:

• Vapor Pressure: 6.17E-07mmHg at 25°C
• Boiling Point: 410.1 °C at 760 mmHg
• Flash Point: 173.6 °C
• PSA: 41.13000
• Density: 1.128 g/cm³
• LogP: 2.02650
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 240.1029409
• Heavy Atom Count: 16
• Complexity: 206

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Phenyl-4-piperidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C(=O)NC2=CC=CC=C2.Cl

Technology Process of N-Phenyl-4-piperidinecarboxamide hydrochloride

There total 9 articles about N-Phenyl-4-piperidinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 4[(phenylamino)carbonyl]piperidine-1-carboxylate (162881-76-7) → N-phenyl-4-piperidinecarboxamide (73415-85-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 5 - 10 ℃; Inert atmosphere;

Reference yield: 57.0%

N-phenylisonicotinamide (3034-31-9) → N-phenyl-4-piperidinecarboxamide (73415-85-7)

Guidance literature:

With potassium hydroxide; aluminum nickel; In methanol; for 18.1h; Heating;

DOI:10.1021/jo00354a021

Reference yield:

aniline (62-53-3) → N-phenyl-4-piperidinecarboxamide (73415-85-7)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 30 ℃; under 2585.7 Torr;

DOI:10.1021/jm00389a007

upstream raw materials:

N-phenylisonicotinamide

aniline

isonipecotic acid

1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid

Downstream raw materials:

1-benzyl-N-phenylpiperidine-4-carboxamide

N-phenyl-1-(4-chlorobenzyl)piperidine-4-carboxamide

N-phenyl-1-(4-methylbenzyl)piperidine-4-carboxamide

Refernces

• 1、 Trivedi, Prakruti,Adhikari, Nilanjan,Amin, Sk. Abdul,Bobde, Yamini,Ganesh, Routholla,Jha, Tarun,Ghosh, Balaram. "Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity". . . Retrieved 2019/08/20.
• 2、 -. "PIPERIDINE UREAS AS CATHEPSIN CYSTEINE PROTEASE INHIBITORS". . . Retrieved 2016/03/14.