C₄₆H₄₄N₆O₃

Base Information

• Chemical Name: C₄₆H₄₄N₆O₃
• CAS No.: 503155-66-6
• Molecular Formula: C₄₆H₄₄N₆O₃
• Molecular Weight: 728.894
• Mol file: 503155-66-6.mol

Synonyms:C₄₆H₄₄N₆O₃

Chemical Property of C₄₆H₄₄N₆O₃

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₆H₄₄N₆O₃

There total 1 articles about C₄₆H₄₄N₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H20N2O3 (503155-65-5) + N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → C46H44N6O3 (503155-66-6)

Guidance literature:

With lithium hydride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.12.116

Reference yield:

C46H44N6O3 (503155-66-6) → Fimasartan (247257-48-3)

Guidance literature:

Multi-step reaction with 4 steps

1: water; sodium hydroxide / methanol / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform

3: Lawessons reagent / toluene / Reflux

4: hydrogenchloride; water / methanol / Reflux

With Lawessons reagent; 4-methyl-morpholine; hydrogenchloride; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; chloroform; toluene;

DOI:10.1016/j.bmcl.2011.12.116

Reference yield:

C46H44N6O3 (503155-66-6) → C44H40N6O3 (1361024-33-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.12.116

upstream raw materials:

C₁₃H₂₀N₂O₃

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Downstream raw materials:

C₃₁H₃₅N₇O₄

C₃₀H₃₄N₈O₃

C₃₀H₃₆N₈O₂

C₂₉H₃₃N₇O₂S

Refernces