(2R)-1,4-Dioxane-2-methanol

Base Information

• Chemical Name: (2R)-1,4-Dioxane-2-methanol
• CAS No.: 406913-88-0
• Molecular Formula: C5H10O3
• Molecular Weight: 118.133
• Hs Code.: 2932990090
• Mol file: 406913-88-0.mol

Synonyms:(2R)-1,4-Dioxane-2-methanol;1,4-Dioxane-2-methanol, (2R)-;(R)-(1,4-Dioxan-2-yl)Methanol;(2R)-1,4-DIOXAN-2-YLMETHANOL

Chemical Property of (2R)-1,4-Dioxane-2-methanol

Chemical Property:

• Boiling Point: 208.2±15.0 °C(Predicted)
• PKA: 14.24±0.10(Predicted)
• PSA: 38.69000
• Density: 1.102
• LogP: -0.60590
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

(R)-(1,4-Dioxan-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-1,4-Dioxane-2-methanol

There total 10 articles about (2R)-1,4-Dioxane-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2R)-2-[(benzyloxy)methyl]-1,4-dioxane → (R)-(-)-2-hydroxymethyl-1,4-dioxane (406913-88-0,143669-41-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 18h;

Reference yield: 48.0%

(1S,5R)-3,6,8-trioxabicyclo[3.2.1]octane (406913-87-9) → (R)-(-)-2-hydroxymethyl-1,4-dioxane (406913-88-0,143669-41-4)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride;

Reference yield: 36.0%

(2R)-2-[(2-chloroethoxy)methyl]oxirane (861852-08-6) → (R)-(-)-2-hydroxymethyl-1,4-dioxane (406913-88-0,143669-41-4)

Guidance literature:

With sodium hydroxide; at 90 ℃; for 2h;

DOI:10.1016/j.bmcl.2005.05.013

upstream raw materials:

(1S,5R)-3,6,8-trioxabicyclo[3.2.1]octane

Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester

(2R)-2-[(2-chloroethoxy)methyl]oxirane

(S)-1-(2-chloroethoxy)-3-chloropropan-2-ol

Downstream raw materials:

((2S)-1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate

MK-2461

benzyl {[[(2R)-1,4-dioxan-2-ylmethyl](methyl)amino]sulfonyl}carbamate

(R)-2-[(2-phenethyl-1,3-dithian-2-yl)methyl]-1,4-dioxane

Refernces

• 1、 -. "1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES". Page/Page column 235. . Retrieved 2016/07/05.
• 2、 Kim, Ha Young,Kuhn, Richard J.,Patkar, Chinmay,Warrier, Ranjit,Cushman, Mark. "Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication". . p. 2667 - 2679. Retrieved 2008/02/07.