GABAPENTIN-D6 HYDROCHLORIDE

Base Information

• Chemical Name: GABAPENTIN-D6 HYDROCHLORIDE
• CAS No.: 6014-29-5
• Molecular Formula: C₁₁H₁₅NO₄*ClH
• Molecular Weight: 261.705
• Mol file: 6014-29-5.mol

Synonyms:GABAPENTIN-D6 HYDROCHLORIDE;1-(aminomethyl)cyclohexaneacetic acid hydrochloride;Neurontin hydrochloride;2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride;Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1)

Chemical Property of GABAPENTIN-D6 HYDROCHLORIDE

Chemical Property:

• Melting Point: 148-151℃ (ethanol )

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GABAPENTIN-D6 HYDROCHLORIDE

There total 1 articles about GABAPENTIN-D6 HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine (555-30-6,555-29-3,88620-56-8) → αMeDopa-OMe*HCl (6014-29-5,115054-62-1)

Guidance literature:

With thionyl chloride; at 60 ℃; for 168h;

DOI:10.1055/s-1991-26380

Reference yield:

αMeDopa-OMe*HCl (6014-29-5,115054-62-1) → 1,α-MeDopa4,2-Ind8>angiotensin II

Guidance literature:

Multi-step reaction with 7 steps

1: NaHCO₃ / dimethylformamide; 2-methyl-propan-2-ol / 120 h / 60 °C

2: Me₄NOH / dimethylformamide; 2-methyl-propan-2-ol; methanol / 72 h / 60 °C

3: 4N NaOH / dioxane / 96 h / 60 °C

5: HOBt, DCC / dimethylformamide / 120 h / 60 °C

6: H₂ / Pd/C / dimethylformamide / 96 h / 2068.6 Torr / Ambient temperature

7: CF₃CO₂H / CH₂Cl₂ / 0.75 h

With sodium hydroxide; tetramethyl ammoniumhydroxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1055/s-1991-26380

Reference yield:

αMeDopa-OMe*HCl (6014-29-5,115054-62-1) → C55H79N13O13

Guidance literature:

Multi-step reaction with 6 steps

1: NaHCO₃ / dimethylformamide; 2-methyl-propan-2-ol / 120 h / 60 °C

2: Me₄NOH / dimethylformamide; 2-methyl-propan-2-ol; methanol / 72 h / 60 °C

3: 4N NaOH / dioxane / 96 h / 60 °C

5: HOBt, DCC / dimethylformamide / 120 h / 60 °C

6: H₂ / Pd/C / dimethylformamide / 96 h / 2068.6 Torr / Ambient temperature

With sodium hydroxide; tetramethyl ammoniumhydroxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1055/s-1991-26380

upstream raw materials:

methanol

3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine

Downstream raw materials:

Boc-αMeDopa-OMe

Boc-αMeDopa(CH2Ph)2-OMe

Boc-αMeDopa(CH2Ph)2

Refernces