2-Hydroxy-5-(hydroxymethyl)benzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-5-(hydroxymethyl)benzaldehyde
• CAS No.: 74901-08-9
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID30225880
• Nikkaji Number: J1.321.833A
• Wikidata: Q83105074
• Mol file: 74901-08-9.mol

Synonyms:2-hydroxy-5-(hydroxymethyl)benzaldehyde;74901-08-9;BRN 3237579;3-08-00-02136 (Beilstein Handbook Reference);5-(Hydroxymethyl)salicylaldehyde;BENZALDEHYDE, 2-HYDROXY-5-(HYDROXYMETHYL)-;2-HYDROXY-5-HYDROXYMETHYL-BENZALDEHYDE;Salicylaldehyde, 5-(hydroxymethyl)-;2-hydroxy-5-hydroxymethylbenzaldehyde;5-hydroxymethylsalicylaldehyde;5-hydroxymethyl-salicylaldehyde;SCHEMBL5528390;DTXSID30225880;2-hydroxy-5-methylol-benzaldehyde;AMY20713;MFCD00456941;AKOS005174406;AS-10650;LS-25067;CS-0102097;D76276;EN300-221205;A1-23726;Z1198153315

Chemical Property of 2-Hydroxy-5-(hydroxymethyl)benzaldehyde

Chemical Property:

• Vapor Pressure: 0.000335mmHg at 25°C
• Boiling Point: 306.5°Cat760mmHg
• PKA: 7.95±0.18(Predicted)
• Flash Point: 153.4°C
• PSA: 57.53000
• Density: 1.342g/cm³
• LogP: 0.69700
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 152.047344113
• Heavy Atom Count: 11
• Complexity: 135

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxy-5-(hydroxymethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CO)C=O)O

Technology Process of 2-Hydroxy-5-(hydroxymethyl)benzaldehyde

There total 9 articles about 2-Hydroxy-5-(hydroxymethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-(chloromethyl)salicylaldehyde (23731-06-8) → 5-hydroxymethylsalicylaldehyde (74901-08-9)

Guidance literature:

With water; copper(II) sulfate; In dimethyl sulfoxide; at 110 ℃; for 2h;

DOI:10.1002/chem.201602292

Reference yield: 84.0%

C20H21NO2 (287398-51-0) → 5-hydroxymethylsalicylaldehyde (74901-08-9)

Guidance literature:

With ozone; In methanol; at -78 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(00)00516-5

Reference yield:

salicylaldehyde (90-02-8) → 5-hydroxymethylsalicylaldehyde (74901-08-9)

Guidance literature:

With hydrogenchloride; formaldehyd; und Auskochen des Produkts mit Wasser;

upstream raw materials:

salicylaldehyde

5-chlorosalicyclaldehyde

C₂₀H₂₁NO₂

formaldehyd

Downstream raw materials:

5-formyl-2-hydroxybenzaldehyde

6-methyl-2-oxo-2H-chromene-3-carboxylic acid

C₁₆H₁₇NO₃

phenyl 6-(hydroxymethyl)-2-oxo-2H-1-benzopyran-3-carboxylate

Refernces

• 1、 Jiang, Nan,Li, Chen,Wang, Guang,Zhong, Tianyuan. "A highly selective fluorescence and absorption sensor for rapid recognition and detection of Cu2+ ions in aqueous solution and film". . . Retrieved 2022/01/19.
• 2、 Kadwa, Ebrahim,Friedrich, Holger B.,Bala, Muhammad D.. "Structural Identification of Products from the Chloromethylation of Salicylaldehyde". . p. 44 - 48. Retrieved 2019/01/04.