N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine

Base Information

• Chemical Name: N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine
• CAS No.: 227000-85-3
• Molecular Formula: C23H32ClNO
• Molecular Weight: 373.966
• Mol file: 227000-85-3.mol

Synonyms:N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine

Chemical Property of N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine

Chemical Property:

• Melting Point: 43-47°C
• Boiling Point: 461.3±55.0 °C(Predicted)
• PKA: 2.78±0.70(Predicted)
• Flash Point: >110℃
• PSA: 12.47000
• Density: 1.043±0.06 g/cm3(Predicted)
• LogP: 6.91580
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-tert-Butyl-O-[1-[4-(chloromethyl)phenyl]ethyl]-N-(2-methyl-1-phenylpropyl)hydroxylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: O,C
• Statements: 8-34
• Safety Statements: 17-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Block Copolymer Synthesis Using a Commercially Available NMP Inititator

Technology Process of N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine

There total 3 articles about N-tert-Butyl-O-[1-[4-(chloroMethyl)phenyl]ethyl]-N-(2-Methyl-1-phenylpropyl)hydroxylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.1%

4-Vinylbenzyl chloride (1592-20-7,29296-32-0) + N-(tert-butyl)-N-(2-methyl-1-phenylpropyl)-N-oxyl (61015-94-9) → N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine (227000-85-3)

Guidance literature:

With sodium tetrahydroborate; (salen)Mn; In ethanol; benzene; at 20 ℃; for 15h;

DOI:10.1021/ja070748i

Reference yield: 63.1%

→ N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine (227000-85-3)

Guidance literature:

Reference yield:

(Z)-2-methyl-N-(2-methylpropylidene)propan-2-amine N-oxide (85664-55-7) → N-tert-butyl-O-[1-(4-chloromethyl-phenyl)-ethyl]-N-(2-methyl-1-phenyl-propyl)-hydroxylamine (227000-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) Cu(OAc)2, conc. aq. NH₃, air / 1.) THF, Et₂O, RT, 12 h, 2.) THF, Et₂O, MeOH, 10 min

2: 62 percent / manganese(III) chloride, di-tert-butyl peroxide, NaBH₄ / toluene; ethanol / 12 h / Ambient temperature

With ammonium hydroxide; sodium tetrahydroborate; copper diacetate; air; [(R,R)-(N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato)]manganese(III) chloride; di-tert-butyl peroxide; In ethanol; toluene;

DOI:10.1021/ja984013c

upstream raw materials:

4-Vinylbenzyl chloride

N-(tert-butyl)-N-(2-methyl-1-phenylpropyl)-N-oxyl

(Z)-2-methyl-N-(2-methylpropylidene)propan-2-amine N-oxide

Downstream raw materials:

2,2,5-trimethyl-3-(1'-(4''-acetoxymethyl)phenylethoxy)-4-phenyl-3-azahexane

O-(1-(4-(azidomethyl)phenyl)ethyl)-N-(tert-butyl)-N-(2-methyl-1-phenylpropyl)hydroxylamine

2,2,5-trimethyl-3-(1-(4-dioctylphosphorylmethyl)phenylethoxy)-4-phenyl-3-azahexane

2,2,5-trimethyl-3-(1'-(4''-hydroxymethyl)phenylethoxy)-4-phenyl-3-azahexane

Refernces

• 1、 Lee, Sang-Min,Chen, Haimei,Dettmer, Christine M.,O'Halloran, Thomas V.,Nguyen, Sonbinh T.. "Polymer-caged lipsomes: A pH-responsive delivery system with high stability". . p. 15096 - 15097. Retrieved 2008/09/18.