4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID

Base Information

• Chemical Name: 4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID
• CAS No.: 41764-07-2
• Molecular Formula: C₁₁H₁₀O₅
• Molecular Weight: 222.197
• Mol file: 41764-07-2.mol

Synonyms:4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID

Chemical Property of 4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID

Chemical Property:

• Vapor Pressure: 1.79E-09mmHg at 25°C
• Boiling Point: 465.7°C at 760 mmHg
• Flash Point: 189°C
• Density: 1.39g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

4-[3,4-(Methylenedioxy)phenyl]-4-oxobutyricacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID

There total 8 articles about 4-[3,4-(METHYLENEDIOXY)PHENYL]-4-OXOBUTYRIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(Benzo<1,2-d><1,3>dioxol-5-yl)-3-cyan-propan-1-on (70770-04-6) → 3-(3',4'-methylenedioxybenzoyl) propanoic acid (41764-07-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1007/BF00764712

Reference yield:

succinic acid anhydride (108-30-5) + 1,2-(methylenedioxy)-4-bromobenzene (2635-13-4) → 3-(3',4'-methylenedioxybenzoyl) propanoic acid (41764-07-2)

Guidance literature:

With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2013.07.125

Reference yield:

3-chloro-1-(1,2-methylenedioxybenzen-4-yl)-propanone (84707-83-5) → 3-(3',4'-methylenedioxybenzoyl) propanoic acid (41764-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / dimethylsulfoxide / 3 h / Heating

2: 77 percent / KOH / aq. ethanol / 4 h / Heating

With potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1007/BF00764712

upstream raw materials:

succinic acid anhydride

Methylenedioxybenzene

1-(Benzo<1,2-d><1,3>dioxol-5-yl)-3-cyan-propan-1-on

aluminium trichloride

Downstream raw materials:

C₁₇H₂₂O₈

C₂₃H₂₇NO₁₂

C₁₇H₂₂O₈

Refernces

• 1、 Chavan, Subhash P.,Garai, Sumanta,Dey, Chandan,Gonnade, Rajesh G.. "A highly stereocontrolled asymmetric total synthesis of epimer of (+)-7-deoxypancratistatin". . p. 5562 - 5566. Retrieved 2013/09/23.