(3-Chloro-2-forMylphenyl)boronic acid

Base Information

• Chemical Name: (3-Chloro-2-forMylphenyl)boronic acid
• CAS No.: 928048-11-7
• Molecular Formula: C₇H₆BClO₃
• Molecular Weight: 184.387
• Mol file: 928048-11-7.mol

Synonyms:(3-Chloro-2-forMylphenyl)boronic acid

Chemical Property of (3-Chloro-2-forMylphenyl)boronic acid

Chemical Property:

• Boiling Point: 386.8±52.0 °C(Predicted)
• PKA: 7.21±0.53(Predicted)
• PSA: 57.53000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: -0.16770
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

(3-Chloro-2-formylphenyl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-2-formylphenylboronic acid

Technology Process of (3-Chloro-2-forMylphenyl)boronic acid

There total 3 articles about (3-Chloro-2-forMylphenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-bromo-3-chloro-2-(dimethoxymethyl)benzene → 3-chloro-2-carbaldehyde phenylboronic acid (928048-11-7)

Guidance literature:

1-bromo-3-chloro-2-(dimethoxymethyl)benzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.25h;

With triethyl borate; In diethyl ether; at -78 - -50 ℃; for 0.5h; Further stages.;

DOI:10.1039/b611195e

Reference yield: 71.28%

1-bromo-3-chloro-2-(dimethoxymethyl)benzene + Trimethyl borate (121-43-7,63156-11-6) + water (7732-18-5) → 3-chloro-2-carbaldehyde phenylboronic acid (928048-11-7)

Guidance literature:

1-bromo-3-chloro-2-(dimethoxymethyl)benzene; Trimethyl borate; With n-butyllithium; In diethyl ether; at -78 - -50 ℃; for 0.75h;

water monomer; With hydrogenchloride; at 70 ℃;

Reference yield:

2-bromo-6-chlorobenzaldehyde (64622-16-8) → 3-chloro-2-carbaldehyde phenylboronic acid (928048-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / H₂SO₄ / methanol / 1 h / Heating

2.1: BuLi / diethyl ether / 0.25 h / -78 °C

2.2: 75 percent / B(OEt)3 / diethyl ether / 0.5 h / -78 - -50 °C

With n-butyllithium; sulfuric acid; In methanol; diethyl ether;

DOI:10.1039/b611195e

upstream raw materials:

2-bromo-6-chlorobenzaldehyde

Trimethyl borate

water

Refernces

• 1、 Lulinski, Sergiusz,Madura, Izabela,Serwatowski, Janusz,Szatylowicz, Halina,Zachara, Janusz. "A tautomeric equilibrium between functionalized 2-formylphenylboronic acids and corresponding 1,3-dihydro-1,3-dihydroxybenzo[c][2,1]oxaboroles". . p. 144 - 154. Retrieved 2007/10/03.