9α-Hydroxyprogesterone

Base Information

• Chemical Name: 9α-Hydroxyprogesterone
• CAS No.: 15981-54-1
• Molecular Formula: C21H30O3
• Molecular Weight: 330.467
• Mol file: 15981-54-1.mol

Synonyms:9-Hydroxypregn-4-ene-3,20-dione;9-Hydroxyprogesterone;9α-Hydroxyprogesterone

Chemical Property of 9α-Hydroxyprogesterone

Chemical Property:

• Melting Point: 190-192 °C
• Boiling Point: 482.9±45.0 °C(Predicted)
• PKA: 14.20±0.70(Predicted)
• PSA: 54.37000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 3.83840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9α-Hydroxyprogesterone

There total 9 articles about 9α-Hydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

Progesterone (57-83-0) → 14-hydroxy-4-pregnene-3,20-dione (16031-66-6) + 9α-hydroxypregn-4-ene-3,20-dione (15981-54-1)

Guidance literature:

With sodium nitrate; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; cornsteep liquor; potassium chloride; magnesium sulfate; iron(II) sulfate; In acetone; at 27 ℃; for 24h; Thamnostylum piriforme ATCC 8992;

DOI:10.1016/0039-128X(95)00006-C

Reference yield: 8.6%

Progesterone (57-83-0) → 14-hydroxy-4-pregnene-3,20-dione (16031-66-6) + 9α-hydroxypregn-4-ene-3,20-dione (15981-54-1) + 6β-hydroxypregn-4-en-3,20-dione (604-19-3) + 2beta-Hydroxyprogesterone (604-29-5,604-28-4,123287-83-2)

Guidance literature:

With C_. emersonii; In 1,4-dioxane; for 360h; Further byproducts given; Ambient temperature;

DOI:10.1016/S0031-9422(00)90396-0

Reference yield: 8.6%

Progesterone (57-83-0) → 21-Hydroxyprogesterone (64-85-7) + 9α-hydroxypregn-4-ene-3,20-dione (15981-54-1) + 6β-hydroxypregn-4-en-3,20-dione (604-19-3) + 2beta-Hydroxyprogesterone (604-29-5,604-28-4,123287-83-2)

Guidance literature:

With C_. emersonii; In 1,4-dioxane; for 360h; Further byproducts given; Ambient temperature;

DOI:10.1016/S0031-9422(00)90396-0

upstream raw materials:

Progesterone

Downstream raw materials:

pregna-4,9⁽¹¹⁾-diene-3,20-dione

pregna-4,8⁽⁹⁾-diene-3,20-dione

9-alpha-hydroxyandrost-4-ene-3,17-dione

Refernces

• 1、 Pollio, Antonino,Pinto, Gabriele,Della Greca, Marina,Fiorentino, Antonio,Previtera, Lucio. "Biotransformations of progesterone by Chlorella spp.". . p. 685 - 688. Retrieved 2007/10/03.
• 2、 Azerad, Robert. "Microbial transformation of steroids: Contribution to 14α-hydroxylations". . p. 337 - 352. Retrieved 2007/10/02.