1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile

Base Information

• Chemical Name: 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile
• CAS No.: 29786-43-4
• Molecular Formula: C12H10F3N
• Molecular Weight: 225.213
• Hs Code.: 2926909090
• Mol file: 29786-43-4.mol

Synonyms:1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile

Chemical Property of 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 3.65068

Purity/Quality:

97% ^*data from raw suppliers

1-[3-(trifluoromethyl)phenyl]cyclobutane-1-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile

There total 2 articles about 1-(3-(TrifluoroMethyl)phenyl)cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.4%

1,3-dibromo-propane (109-64-8) + 3-trifluoromethylphenylacetonitrile (2338-76-3) → 1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carbonitrile (29786-43-4)

Guidance literature:

With sodium hydride; In tert-butyl methyl ether; dimethyl sulfoxide; mineral oil; for 12h;

Reference yield: 56.3%

→ 1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carbonitrile (29786-43-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -10 - 0 ℃; for 1h; Inert atmosphere;

In N,N-dimethyl-formamide; mineral oil; at -10 - 10 ℃;

Reference yield: 98.0%

1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carbonitrile (29786-43-4) → 1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carboxamide (29786-53-6)

Guidance literature:

With tetrabutylammomium bromide; dihydrogen peroxide; sodium hydroxide; In methanol; at 20 ℃; for 18h;

upstream raw materials:

1,3-dibromo-propane

3-trifluoromethylphenylacetonitrile

Downstream raw materials:

1-(3-(trifluoromethyl)phenyl)cyclobutane-1-carboxamide

<1-(α,α,α-Trifluor-m-tolyl)-cyclobutyl>-carbonylisocyanat

(<1-(α,α,α-Trifluor-m-tolyl)-cyclobutyl>-carbonyl)-harnstoff

(<1-(α,α,α-Trifluoro-m-tolyl)cyclobutyl>carbonyl)carbamsaeuremethylester

Refernces

• 1、 -. "Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same". Paragraph 0554-0557. . Retrieved 2017/07/18.
• 2、 -. "NOVEL TRPV3 MODULATORS". Paragraph 1678; 1679. . Retrieved 2013/06/04.