6,7-Dihydrothieno[3,2-c]pyridine

Base Information

• Chemical Name: 6,7-Dihydrothieno[3,2-c]pyridine
• CAS No.: 107112-93-6
• Molecular Formula: C7H7NS
• Molecular Weight: 137.205
• DSSTox Substance ID: DTXSID20544436
• Nikkaji Number: J3.660.672J
• Wikidata: Q82421535
• Mol file: 107112-93-6.mol

Synonyms:6,7-Dihydrothieno[3,2-c]pyridine;107112-93-6;6,7-Dihydrothieno[3,2-C]-pyridine;SCHEMBL19437124;DTXSID20544436

Chemical Property of 6,7-Dihydrothieno[3,2-c]pyridine

Chemical Property:

• Boiling Point: 258.7±29.0 °C(Predicted)
• PKA: 5.29±0.20(Predicted)
• PSA: 40.60000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 1.15870
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 137.02992040
• Heavy Atom Count: 9
• Complexity: 133

Purity/Quality:

98% ^*data from raw suppliers

6,7-Dihydrothieno[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=CC2=C1SC=C2
• Uses: 6,7-Dihydrothieno[3,2-C]-pyridine can be used in the synthesis of thieno[3,2-a]quinolizidines and attempts to prepare Papaverine analogs. Used in the synthesis of thieno[3,2-a]quinolizidines and attempts to prepare Papaverine analogs.

Technology Process of 6,7-Dihydrothieno[3,2-c]pyridine

There total 7 articles about 6,7-Dihydrothieno[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-(thien-2-yl)ethyl)formamide (28783-49-5) → dihydro-6,7 thieno<3,2-c>pyridine (107112-93-6)

Guidance literature:

With PPA; trichlorophosphate;

DOI:10.1021/ja01618a031

Reference yield:

2-cyanomethylthiophene (20893-30-5) → dihydro-6,7 thieno<3,2-c>pyridine (107112-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium alanate; diethyl ether

3: polyphosphoric acid; POCl₃

With lithium aluminium tetrahydride; PPA; diethyl ether; trichlorophosphate;

DOI:10.1021/ja01618a031

Reference yield:

[2-(2-thyenyl)ethyl]amine (30433-91-1) → dihydro-6,7 thieno<3,2-c>pyridine (107112-93-6)

Guidance literature:

Multi-step reaction with 2 steps

2: polyphosphoric acid; POCl₃

With PPA; trichlorophosphate;

DOI:10.1021/ja01618a031

upstream raw materials:

N-(2-(thien-2-yl)ethyl)formamide

phosphoric acid

trichlorophosphate

2-cyanomethylthiophene

Downstream raw materials:

1,3-diphenyl-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

Refernces