N-(4-ethoxyphenyl)-2-hydroxyacetamide

Base Information

• Chemical Name: N-(4-ethoxyphenyl)-2-hydroxyacetamide
• CAS No.: 22521-79-5
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• UNII: SP28AL52TM
• DSSTox Substance ID: DTXSID20177041
• Nikkaji Number: J11.496K
• Wikidata: Q27289323
• NCI Thesaurus Code: C65633
• ChEMBL ID: CHEMBL2106268
• Mol file: 22521-79-5.mol

Synonyms:N-(4-ethoxyphenyl)-2-hydroxyacetamide;22521-79-5;p-Ethoxyglycolanilide;Fenacetinol [INN:DCF];Fenacetinolum;N-(4-Ethoxyphenyl)glycolamide;UNII-SP28AL52TM;Fenacetinolum [INN-Latin];SP28AL52TM;Oxyphenacetin;p-Glycolophenetidide.;FENACETINOL [INN];MLS006011940;SCHEMBL2850567;CHEMBL2106268;DTXSID20177041;N-(Hydroxyacetyl)-4-ethoxyaniline;AMY10575;AKOS000125277;SB84956;SMR002529485;Acetamide, N-(4-ethoxyphenyl)-2-hydroxy-;FT-0750663;EN300-54629;L10174;SR-01000944877;A1-05992;N-(4-ethoxyphenyl)-2-hydroxyacetamide, AldrichCPR;SR-01000944877-1;Q27289323;Z228585500

Chemical Property of N-(4-ethoxyphenyl)-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 1.48E-07mmHg at 25°C
• Melting Point: 149-150℃
• Boiling Point: 412.9°Cat760mmHg
• Flash Point: 203.5°C
• PSA: 58.56000
• Density: 1.216g/cm³
• LogP: 1.08910
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-ethoxyphenyl)-2-hydroxyacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)NC(=O)CO

Technology Process of N-(4-ethoxyphenyl)-2-hydroxyacetamide

There total 4 articles about N-(4-ethoxyphenyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethoxyacetanilide (62-44-2,105931-34-8) → 4-acetaminophenol (103-90-2,8055-08-1) + glycolic acid p-phenetidide (22521-79-5)

Guidance literature:

With human cytochrome CYP₁A₂; at 37 ℃; pH=7.4; Kinetics; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.molcatb.2010.01.017

Reference yield:

4-Ethoxyaniline (156-43-4) → glycolic acid p-phenetidide (22521-79-5)

Guidance literature:

at 130 ℃;

Reference yield:

4-Ethoxyaniline (156-43-4) → glycolic acid p-phenetidide (22521-79-5)

Guidance literature:

at 150 - 200 ℃;

upstream raw materials:

4-Ethoxyaniline

4-ethoxyacetanilide

Downstream raw materials:

ethoxycarbonyloxy-acetic acid p-phenetidide

Refernces