CID 20054835

Base Information Edit

Chemical Name:CID 20054835
CAS No.:71963-77-4
Molecular Formula:C16H26O5
Molecular Weight:298.379
Hs Code.:29329930
European Community (EC) Number:663-549-0
Wikipedia:Artemether
Mol file:71963-77-4.mol

Synonyms:71963-77-4;(5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene

Suppliers and Price of CID 20054835

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Artemether
20mg
$ 255.00

TRC
Artemether
5g
$ 305.00

Tocris
Artemether ≥98%(HPLC)
50
$ 54.00

TCI Chemical
Artemether >98.0%(HPLC)
25g
$ 195.00

TCI Chemical
Artemether >98.0%(HPLC)
5g
$ 66.00

Sigma-Aldrich
Artemether ≥98% (HPLC)
5mg
$ 76.10

Sigma-Aldrich
Artemether United States Pharmacopeia (USP) Reference Standard
100mg
$ 366.00

Sigma-Aldrich
Artemether ≥98% (HPLC)
25mg
$ 293.00

Medical Isotopes, Inc.
Artemether
1 g
$ 290.00

JR MediChem
Artemether 98%
5g
$ 368.00

Total 262 raw suppliers

Chemical Property of CID 20054835 Edit

Chemical Property:

Melting Point:86-89oC
Refractive Index:1.518
Boiling Point:357.5 °C at 760 mmHg
Flash Point:140.5 °C
PSA：46.15000
Density:1.18 g/cm³
LogP:2.84080
Storage Temp.:room temp
Solubility.:DMSO: ≥20mg/mL
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:298.17802393
Heavy Atom Count:21
Complexity:429

Purity/Quality:

99%, ^*data from raw suppliers

Artemether ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C
Isomeric SMILES:C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3C24[C@H]1CCC(O3)(OO4)C)OC)C
Description Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Uses Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant. atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when

Technology Process of CID 20054835

There total 18 articles about CID 20054835 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%