Teneligliptin

Base Information

• Chemical Name: Teneligliptin
• CAS No.: 906093-29-6
• Molecular Formula: C44H65Br5N12O2S2
• Molecular Weight: 628.86（无水）
• UNII: 556RZT8JPF
• DSSTox Substance ID: DTXSID90238219
• Wikidata: Q27261290
• Mol file: 906093-29-6.mol

Synonyms:teneligliptin（INN）

Chemical Property of Teneligliptin

Chemical Property:

• PSA: 163.88000
• LogP: 8.46190
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly)
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 8
• Exact Mass: 1256.06708
• Heavy Atom Count: 65
• Complexity: 594

Purity/Quality:

97% ^*data from raw suppliers

TeneligliptinHydrobromide(2:5) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br
• Isomeric SMILES: CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br
• Uses: Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
• Clinical Use: Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia?. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.