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Gatifloxacin sesquihydrate

Base Information Edit
  • Chemical Name:Gatifloxacin sesquihydrate
  • CAS No.:160738-57-8
  • Molecular Formula:C22H28FN3O7
  • Molecular Weight:465.47200
  • Hs Code.:2933990090
  • European Community (EC) Number:672-577-2
  • UNII:L4618BD7KJ
  • NCI Thesaurus Code:C29070
  • RXCUI:228476
  • Mol file:160738-57-8.mol
Gatifloxacin sesquihydrate

Synonyms:1-cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;AM 1155;AM-1155;BMS 206584;BMS-206584;BMS206584;CG 5501;gatifloxacin;gatifloxacine;Tequin;Zymar

Suppliers and Price of Gatifloxacin sesquihydrate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Biorbyt Ltd
  • Gatifloxacin hydrochloride
  • 1 g
  • $ 397.80
  • American Custom Chemicals Corporation
  • GATIFLOXACIN LACTATE 95.00%
  • 5MG
  • $ 503.44
  • AHH
  • Gatifloxacinlactate 98%
  • 25g
  • $ 880.00
Total 86 raw suppliers
Chemical Property of Gatifloxacin sesquihydrate Edit
Chemical Property:
  • Vapor Pressure:1.73E-16mmHg at 25°C 
  • Melting Point:162oC 
  • Boiling Point:625.1oC at 760 mmHg 
  • Flash Point:331.8oC 
  • PSA:141.33000 
  • LogP:1.82600 
  • Hydrogen Bond Donor Count:7
  • Hydrogen Bond Acceptor Count:19
  • Rotatable Bond Count:8
  • Exact Mass:804.35056276
  • Heavy Atom Count:57
  • Complexity:653
Purity/Quality:

99% *data from raw suppliers

Gatifloxacin hydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-27-36/37/39 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F.O.O.O
  • Description Gatifloxacin is a novel orally-active fluoroquinolone antibiotic with a potent and broad spectrum of activity against gram-positive (S.pneumonia, S.aureus) and gram-negative bacteria. It shows good activity against strains resistant to established antituberculosis agents. Gatifloxacin was marketed for the treatment of respiratory tract and urinary infections, particularly the treatment of certain community-acquired infections (such as bronchitis, pneumonia and common sexually-transmitted diseases). Comparative studies with ciprofloxacin, ofloxacin and sparfloxacin against fluoroquinolone-resistant organisms indicated a better or equivalent effectiveness with less phototoxic adverse effects.
Technology Process of Gatifloxacin sesquihydrate

There total 30 articles about Gatifloxacin sesquihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
(+/-)-2-methylpiperazine bis(hydrochloride); 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; With boron trifluoride-tetrahydrofuran complex; triethylamine; In acetonitrile; at 20 ℃; for 25h;
With methanol; for 5h; Reflux;
With sodium hydroxide; In methanol; water; at 20 ℃; for 16h; pH=7;
Guidance literature:
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; With 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 76 - 80 ℃; for 1h; Heating / reflux;
With boron trifluoride diethyl etherate; In acetonitrile; at 0 - 25 ℃; for 2h;
(RS)-2-methylpiperazine; With triethylamine; In acetonitrile; at 15 - 25 ℃; for 3h; pH=~ 9;
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