2-Bromo-5-aminobenzoic acid ethyl ester

Base Information

• Chemical Name: 2-Bromo-5-aminobenzoic acid ethyl ester
• CAS No.: 208176-32-3
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.0852
• Hs Code.: 2922499990
• Mol file: 208176-32-3.mol

Synonyms:Benzoic acid, 5-amino-2-bromo-, ethyl ester;

Chemical Property of 2-Bromo-5-aminobenzoic acid ethyl ester

Chemical Property:

• Boiling Point: 326 °C at 760 mmHg
• Flash Point: 150.9 °C
• PSA: 52.32000
• Density: 1.503 g/cm³
• LogP: 2.78920

Purity/Quality:

99% ^*data from raw suppliers

Ethyl5-amino-2-bromobenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-aminobenzoic acid ethyl ester

There total 1 articles about 2-Bromo-5-aminobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl 2-bromo-5-aminobenzoate (208176-32-3)

Guidance literature:

Reference yield: 60.0%

ethyl 2-bromo-5-aminobenzoate (208176-32-3) + di-tert-butyl dicarbonate (24424-99-5) → ethyl 2-bromo-5-(tert-butoxycarbonylamino)benzoate (1247810-89-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1021/ja107541w

Reference yield:

ethyl 2-bromo-5-aminobenzoate (208176-32-3) + 2,6-difluorobenzoylchloride (18063-02-0) → ethyl 2-bromo-5-(2,6-difluorobenzamido)benzoate (1373940-70-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 15h;

Downstream raw materials:

ethyl 2-bromo-5-(tert-butoxycarbonylamino)benzoate

ethyl 2-bromo-5-(2,6-difluorobenzamido)benzoate

ethyl 4-(2,6-difluorobenzamido)-3'-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-[1,1'-biphenyl]-2-carboxylate

4-(2,6-difluorobenzamido)-3'-(5,5-dimethyl-4-oxo-4,5-dihydroisoxazol-3-yl)-[1,1'-biphenyl]-2-carboxylic acid

Refernces