2-Bromo-5-chlorobenzoic acid ethyl ester

Base Information

• Chemical Name: 2-Bromo-5-chlorobenzoic acid ethyl ester
• CAS No.: 690260-91-4
• Molecular Formula: C9H8BrClO2
• Molecular Weight: 263.518
• Hs Code.: 2916399090
• Mol file: 690260-91-4.mol

Synonyms:Benzoic acid, 5-bromo-2-chloro-, ethyl ester;

Chemical Property of 2-Bromo-5-chlorobenzoic acid ethyl ester

Chemical Property:

• Boiling Point: 291.9 °C at 760 mmHg
• Flash Point: 130.3 °C
• PSA: 26.30000
• Density: 1.532 g/cm³
• LogP: 3.27920

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-5-chlorobenzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-chlorobenzoic acid ethyl ester

There total 2 articles about 2-Bromo-5-chlorobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-chloro-benzoic acid ethyl ester (1128-76-3) → ethyl 2-bromo-5-chlorobenzoate (690260-91-4)

Guidance literature:

With sodium persulfate; N-Bromosuccinimide; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 90 ℃; for 5h; regioselective reaction; Sealed tube;

DOI:10.1002/anie.201300176

Reference yield:

→ ethyl 2-bromo-5-chlorobenzoate (690260-91-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; Inert atmosphere;

Reference yield: 85.0%

ethyl 2-bromo-5-chlorobenzoate (690260-91-4) → 3-chloro-benzoic acid ethyl ester (1128-76-3)

Guidance literature:

With C₅₅H₄₆N₄O₄W; potassium carbonate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h; Irradiation;

DOI:10.1039/d0sc01340d

upstream raw materials:

3-chloro-benzoic acid ethyl ester

Downstream raw materials:

3-chloro-benzoic acid ethyl ester

Refernces

• 1、 Sun, Xiuyun,Shan, Gang,Sun, Yonghui,Rao, Yu. "Regio- and chemoselective C-H chlorination/bromination of electron-deficient arenes by weak coordination and study of relative directing-group abilities". supporting information. p. 4440 - 4444. Retrieved 2013/05/22.