2-Chloro-6-(1-piperazinyl)pyrazine

Base Information

• Chemical Name: 2-Chloro-6-(1-piperazinyl)pyrazine
• CAS No.: 64022-27-1
• Molecular Formula: C8H11ClN4
• Molecular Weight: 235.11
• Hs Code.: 2933990090
• NSC Number: 317326
• UNII: 62C3N7238U
• DSSTox Substance ID: DTXSID80214007
• Nikkaji Number: J22.665C
• Wikipedia: MK-212
• Wikidata: Q15124168
• Pharos Ligand ID: MGGD5D3762QB
• Metabolomics Workbench ID: 153159
• ChEMBL ID: CHEMBL269521
• Mol file: 64022-27-1.mol

Synonyms:2-chloro-6-(1-piperazinyl)pyrazine;6-chloro-2-(1-piperazinyl)pyrazine;6-chloro-2-(1-piperazinyl)pyrazine, monohydrochloride;CPP;MK 212;MK-212;MK212 cpd

Chemical Property of 2-Chloro-6-(1-piperazinyl)pyrazine

Chemical Property:

• Boiling Point: 364.1 °C at 760 mmHg
• Flash Point: 174 °C
• PSA: 41.05000
• Density: 1.272 g/cm³
• LogP: 0.93340
• Storage Temp.: Store at RT
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 198.0672241
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

MK 212 hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CN=CC(=N2)Cl
• Uses: MK 212 Hydrochloride is a 5-HT2C agonist that may possess antipsychotic activity; however, mainly functions as an anti-stress treatment when ingested.

Technology Process of 2-Chloro-6-(1-piperazinyl)pyrazine

There total 3 articles about 2-Chloro-6-(1-piperazinyl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate (426829-52-9) → 6-chloro-2-(1-piperazinyl)pyrazine (64022-27-1)

Guidance literature:

tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate; With macroporous polymer-supported-SO₃H; In dichloromethane; at 20 ℃;

With ammonium hydroxide; In methanol;

DOI:10.1016/j.tetlet.2006.02.047

Reference yield:

piperazine (110-85-0) + 2,6-dichloropyrazine (4774-14-5) → 6-chloro-2-(1-piperazinyl)pyrazine (64022-27-1)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jm801242y

Reference yield:

→ 6-chloro-2-(1-piperazinyl)pyrazine (64022-27-1)

Guidance literature:

entspr. Chlorpyrazin, Piperazin;

DOI:10.1021/jm00204a007

upstream raw materials:

tert-Butyl 4-(6-Chloro-2-Pyrazinyl)-1-Piperazinecarboxylate

piperazine

2,6-dichloropyrazine

Downstream raw materials:

(E)-3-[3-(3,4,5,6-Tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)phenyl]acrylic acid

Refernces

• 1、 More, Kunal N.,Hong, Victor S.,Lee, Ahyeon,Park, Jongsung,Kim, Shin,Lee, Jinho. "Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors". supporting information. p. 2513 - 2517. Retrieved 2018/06/06.
• 2、 Duncton, Matthew A. J.,Roffey, Jonathan R. A.,Hamlyn, Richard J.,Adams, David R.. "Parallel synthesis of N-arylpiperazines using polymer-assisted reactions". . p. 2549 - 2552. Retrieved 2007/10/03.