2-Bromoacetyl-6-methoxynaphtalene

Base Information

• Chemical Name: 2-Bromoacetyl-6-methoxynaphtalene
• CAS No.: 10262-65-4
• Molecular Formula: C13H11BrO2
• Molecular Weight: 279.133
• Hs Code.: 2914700090
• Mol file: 10262-65-4.mol

Synonyms:2-bromo-1-(6-methoxynaphthalen-2-yl)ethanone;2-Bromo-1-(6-methoxy-2-naphthalenyl)ethanone;2-Bromo-1-(6-methoxy-2-naphthyl)ethanone;2-Bromoacetyl-6-methoxynaphthalene;

Chemical Property of 2-Bromoacetyl-6-methoxynaphtalene

Chemical Property:

• Vapor Pressure: 3.35E-06mmHg at 25°C
• Melting Point: 110.0 to 114.0 °C
• Refractive Index: 1.631
• Boiling Point: 387.2 °C at 760 mmHg
• Flash Point: 188 °C
• PSA: 26.30000
• Density: 1.451 g/cm³
• LogP: 3.42600

Purity/Quality:

98% ^*data from raw suppliers

2-(Bromoacetyl)-6-methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Bromoacetyl)-6-methoxynaphthalene is used in the preparation of 2-(2-arylmorpholino)ethyl esters of ibuprofen hydrochlorides as COX-2 and serotonin reuptake inhibitors.

Technology Process of 2-Bromoacetyl-6-methoxynaphtalene

There total 6 articles about 2-Bromoacetyl-6-methoxynaphtalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methoxy-2-acetylnaphthalene (3900-45-6) → 2-bromo-1-(6-methoxy-2-naphthyl)ethanone (10262-65-4)

Guidance literature:

With copper(I) bromide; In ethanol; at 60 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201201422

Reference yield: 48.0%

2-Methoxynaphthalene (93-04-9) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-1-(6-methoxy-2-naphthyl)ethanone (10262-65-4)

Guidance literature:

2-Bromoacetyl bromide; With aluminum (III) chloride; In dichloromethane; at 0 ℃; for 1h;

2-Methoxynaphthalene; In dichloromethane; at 0 ℃; for 5h;

DOI:10.1039/c9cc05604a

Reference yield:

6-methoxy-2-acetylnaphthalene (3900-45-6) → 2-bromo-1-(6-methoxy-2-naphthyl)ethanone (10262-65-4) + α,α'-dibromoacetyl-2 methoxy-6 naphtalene (52997-56-5)

Guidance literature:

With 2-carboxyethyl triphenyl phosphonium tribromide; In tetrahydrofuran; at 25 ℃; for 6h;

upstream raw materials:

6-methoxy-2-acetylnaphthalene

2-Methoxynaphthalene

2-Bromoacetyl bromide

Downstream raw materials:

C₃₄H₃₁Cl₂N₃O₅

C₂₈H₁₉Cl₂N₇O₃

2-(6-methoxynaphthalen-2-yl)-5-(p-tolyl)indolizine

2-[2-(6-methoxynaphthalen-2-yl)morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Refernces

• 1、 Roy, Biswajit,Kundu, Moumita,Singh, Amit Kumar,Singha, Tara,Bhattacharya, Sayantan,Datta, Prasanta Kumar,Mandal, Mahitosh,Singh, N. D. Pradeep. "Stepwise dual stimuli triggered dual drug release by a single naphthalene based two-photon chromophore to reverse MDR for alkylating agents with dual surveillance in uncaging steps". . p. 13140 - 13143. Retrieved 2019.
• 2、 Murár, Miroslav,Dobia?, Juraj,?ramel, Peter,Addová, Gabriela,Hanquet, Gilles,Bohá?, Andrej. "Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands". . p. 754 - 761. Retrieved 2017.
• 3、 -. "VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE". Paragraph 0239. . Retrieved 2016/12/22.