4-Amino-3-phenyl-L-alanine monohydrochloride

Base Information

• Chemical Name: 4-Amino-3-phenyl-L-alanine monohydrochloride
• CAS No.: 62040-55-5
• Molecular Formula: C9H13ClN2O2
• Molecular Weight: 216.667
• Hs Code.: 2922499990
• European Community (EC) Number: 263-388-2,631-131-7
• DSSTox Substance ID: DTXSID50211104
• Mol file: 62040-55-5.mol

Synonyms:62040-55-5;4-Amino-L-phenylalanine hydrochloride;4-Amino-3-phenyl-L-alanine monohydrochloride;H-Phe(4-NH2)-OH.HCl;4-Amino-L-phenylalanine HCl;H-Phe(4-NH2)-OH HCl;p-Amino-L-phenylalanine hydrochloride;4-Amino-L-phenylalanine, HCl;EINECS 263-388-2;4-Amino-3-phenyl-L-alanine HCl;4-Amino-L-phenylalanine (hydrochloride);(2S)-2-amino-3-(4-aminophenyl)propanoic acid;hydrochloride;312693-79-1;MFCD00012986;(S)-2-amino-3-(4-aminophenyl)propanoic acid hydrochloride;L-3-(p-Aminophenyl)alanine Hydrochloride;H-Phe(4-NH2)-OHHCl;SCHEMBL3873365;DTXSID50211104;AKOS015909548;HY-W141810;BS-28947;CS-0201607;L-Phenylalanine, 4-amino-, monohydrochloride;H10530

Chemical Property of 4-Amino-3-phenyl-L-alanine monohydrochloride

Chemical Property:

• Appearance/Colour: Off-White Powder
• Vapor Pressure: 1.44E-06mmHg at 25°C
• Boiling Point: 383.5 °C at 760 mmHg
• Flash Point: 185.8 °C
• PSA: 89.34000
• LogP: 2.30670
• Storage Temp.: -15°C
• Solubility.: Acetic Acid, Water
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 216.0665554
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

98%,99%, ^*data from raw suppliers

p-Amino-L-phenylalanine, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)N)N.Cl
• Isomeric SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)N.Cl
• Uses: p-Amino-L-phenylalanine is an analog of L-Phenylalanine (P319415). An analog of phenylalanine

Technology Process of 4-Amino-3-phenyl-L-alanine monohydrochloride

There total 2 articles about 4-Amino-3-phenyl-L-alanine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-3-phenyl-L-alanine (949-99-5) → L-p-aminophenylalanine dihydrochloride (62040-55-5,93913-56-5,120482-21-5,126257-07-6,139879-21-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on barium sulfate; In water; for 4h; under 760 Torr;

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → L-p-aminophenylalanine dihydrochloride (62040-55-5,93913-56-5,120482-21-5,126257-07-6,139879-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid, nitric acid / 1) room temperature, 24 h, 2) 50 deg C (bath temperature), 2 h

2: H₂, HCl / Pd-BaSO₄ / H₂O / 4 h / 760 Torr

With hydrogenchloride; sulfuric acid; hydrogen; nitric acid; palladium on barium sulfate; In water;

Reference yield: 66.0%

ethanol (4502-04-9) + p-amino-L-phenylalanine hydrochloride (62040-55-5) → C10(14)CH16N2O2 (114422-51-4)

Guidance literature:

With hydrogenchloride; for 40h; Ambient temperature;

DOI:10.1021/jo00297a074

upstream raw materials:

4-nitro-3-phenyl-L-alanine

L-phenylalanine

Downstream raw materials:

C₁₀⁽¹⁴⁾CH₁₆N₂O₂

4-iodo-L-phenylalanine

C₂₀H₃₀N₄O₆

Fmoc-p-(N,N'-Boc-guanidino)Phe

Refernces