1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE

Base Information

• Chemical Name: 1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE
• CAS No.: 1835-61-6
• Molecular Formula: C6HClF4
• Molecular Weight: 184.521
• Hs Code.: 2903999090
• Mol file: 1835-61-6.mol

Synonyms:1-Chloro-2,3,5,6-tetrafluorobenzene;2,3,5,6-Tetrafluorochlorobenzene;

Chemical Property of 1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE

Chemical Property:

• Vapor Pressure: 12.3mmHg at 25°C
• Refractive Index: 1.442
• Boiling Point: 129.7 °C at 760 mmHg
• Flash Point: 42.8 °C
• PSA: 0.00000
• Density: 1.56 g/cm³
• LogP: 2.89640
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3,5,6-Tetrafluorochlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE

There total 11 articles about 1-CHLORO-2,3,5,6-TETRAFLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3,5,6-tetrafluorothiophenol (769-40-4) → 1-chloro-2,3,5,6-tetrafluorobenzene (1835-61-6)

Guidance literature:

With chlorine; at 400 ℃; for 0.305h;

DOI:10.1007/s11178-006-0012-1

Reference yield: 60.0%

1-chloro-2,3,4,5,6-pentafluorobenzene (344-07-0) → 1-chloro-2,3,5,6-tetrafluorobenzene (1835-61-6) + 1-chloro-2,3,4,5-tetrafluorobenzene (769-37-9) + 1-chloro-2,3,4,6-tetrafluorobenzene (5172-06-5)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; HSiPh₃; In tetrahydrofuran; benzene-d6; at 60 ℃; for 40h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201708003

Reference yield:

1-chloro-2,3,4,5,6-pentafluorobenzene (344-07-0) → 1-chloro-2,3,5,6-tetrafluorobenzene (1835-61-6) + Pentafluorobenzene (363-72-4) + Bis(4-chloro-2,3,5,6-tetrafluorophenyl)sulfide (56354-50-8) + 1,4-Bis(4-chloro-2,3,5,6-tetrafluorothiophenoxy)tetrafluorobenzene (56354-52-0)

Guidance literature:

With sodium dithionite; In N,N-dimethyl-formamide; at 110 - 115 ℃; for 54h; Yield given. Yields of byproduct given;

DOI:10.1016/S0022-1139(00)80493-5

upstream raw materials:

1,4-dichloro-2,3,5,6-tetrafluorobenzene

1-chloro-2,3,4,5,6-pentafluorobenzene

1,4-dibromotetrafluorobenzene

4-chloro-2,3,5,6-tetrafluorophenylhydrazine

Downstream raw materials:

4-bromotetrafluorophenyl(pentafluorophenyl)sulfane

(C₆F₄Cl)2Se₂

C₆Cl₂F₄Se

C₁₁ClF₈NSe

Refernces

• 1、 Kikushima, Kotaro,Grellier, Mary,Ohashi, Masato,Ogoshi, Sensuke. "Transition-Metal-Free Catalytic Hydrodefluorination of Polyfluoroarenes by Concerted Nucleophilic Aromatic Substitution with a Hydrosilicate". supporting information. p. 16191 - 16196. Retrieved 2017/11/27.
• 2、 Bredikhin,Maksimov,Gatilov, Yu. V.,Kireenkov,Platonov. "Reactions of polyfluorobenzenethiols with polyhalomethanes and their derivatives in an alkaline medium". . p. 1551 - 1559. Retrieved 2015/12/30.