Benzene, 1-nitro-2-(2-phenylethyl)-

Base Information

• Chemical Name: Benzene, 1-nitro-2-(2-phenylethyl)-
• CAS No.: 6796-01-6
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Mol file: 6796-01-6.mol

Synonyms:

Chemical Property of Benzene, 1-nitro-2-(2-phenylethyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-nitro-2-(2-phenylethyl)-

There total 9 articles about Benzene, 1-nitro-2-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 1-nitro-2-phenethylbenzene (6796-01-6)

Guidance literature:

With indium; iodine; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In N,N-dimethyl acetamide; at 100 ℃;

Reference yield: 86.0%

2-phenethyl iodide (17376-04-4) + o-nitroiodobenzene (609-73-4) → 1-nitro-2-phenethylbenzene (6796-01-6)

Guidance literature:

2-phenethyl iodide; With indium; copper(ll) sulfate pentahydrate; In tetrahydrofuran; water; at 60 ℃; for 12h;

o-nitroiodobenzene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In N,N-dimethyl acetamide; water; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2019.151288

Reference yield: 82.0%

Br(1-)*C14H11NO2 → 1-nitro-2-phenethylbenzene (6796-01-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; Inert atmosphere;

DOI:10.1002/ejic.201101005

upstream raw materials:

trimethyl(2-nitrobenzyl)silane

benzyl bromide

1,1'-(1,2-ethanediyl)bisbenzene

(2-nitrobenzyl)triphenylphosphonium bromide

Downstream raw materials:

9,10-dihydrodibenzazepine

2-phenyl-indole

2-(2-phenylethyl)aniline

Refernces

• 1、 Zhi, Man-Ling,Chen, Bing-Zhi,Deng, Wei,Chu, Xue-Qiang,Loh, Teck-Peng,Shen, Zhi-Liang. "Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions". . p. 3017 - 3023. Retrieved 2019/02/26.
• 2、 Wang, Peng,Chen, Bing-Zhi,Guo, Yi-Cong,Rao, Weidong,Shen, Zhi-Liang. "Copper(II)-catalyzed preparation of alkylindium compounds and applications in cross-coupling reactions both in aqueous media". supporting information. . Retrieved 2019/11/11.