gamma-Glutamyldopa

Base Information

• Chemical Name: gamma-Glutamyldopa
• CAS No.: 52370-58-8
• Molecular Formula: C₁₄H₁₈N₂O₇
• Molecular Weight: 326.306
• DSSTox Substance ID: DTXSID10966749
• Nikkaji Number: J344.561E
• Wikidata: Q76010051
• Mol file: 52370-58-8.mol

Synonyms:gamma-glutamyl DOPA;gamma-glutamyl L-dopa;gamma-glutamyl-3,4-dihydroxyphenylalanine;gludopa

Chemical Property of gamma-Glutamyldopa

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 744°Cat760mmHg
• PKA: 2.22±0.10(Predicted)
• Flash Point: 403.7°C
• Density: 1.498g/cm³
• XLogP3: -3.5
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 326.11140092
• Heavy Atom Count: 23
• Complexity: 443

Purity/Quality:

99% ^*data from raw suppliers

GAMMA-GLUTAMYL DOPA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CC(C(=O)O)NC(=O)CCC(C(=O)O)N)O)O
• Isomeric SMILES: C1=CC(=C(C=C1C[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N)O)O

Technology Process of gamma-Glutamyldopa

There total 2 articles about gamma-Glutamyldopa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-glutamine (56-85-9,26700-71-0) + levodopa (59-92-7,90638-38-3) → γ-glutamyl L-3,4-dihydroxyphenylalanine (52370-58-8)

Guidance literature:

With sodium hydroxide; disodium hydrogenphosphate; γ-glutamyltranspeptidase; sodium chloride; ascorbic acid; In water; for 3.5h; Yield given;

DOI:10.1271/bbb1961.52.1741

Reference yield:

GLUTATHIONE (70-18-8) + levodopa (59-92-7,90638-38-3) → γ-glutamyl L-3,4-dihydroxyphenylalanine (52370-58-8)

Guidance literature:

With γ-glutamyltranspeptidase; sodium chloride; ascorbic acid; at 30 ℃; for 12h; Tris-HCl buffer (pH 9.0);

upstream raw materials:

L-glutamine

levodopa

GLUTATHIONE

Refernces

• 1、 Nakayama, Reiko,Kumagai, Hidehiko,Akashi, Shiro,Sugiura, Hiroyoshi,Tochikura, Tatsurokuro. "Synthesis of γ-Glutamyl L-3,4-Dihydroxyphenylalanine by γ-Glutamyltranspeptidase from Proteus mirabilis". . p. 1041 - 1046. Retrieved 2007/10/02.