1,3-Disiloxanediol, 1,1,3,3-tetramethyl-

Base Information

• Chemical Name: 1,3-Disiloxanediol, 1,1,3,3-tetramethyl-
• CAS No.: 1118-15-6
• Molecular Formula: C4H14 O3 Si2
• Molecular Weight: 166.324
• Hs Code.: 2934999090
• European Community (EC) Number: 214-258-9
• DSSTox Substance ID: DTXSID8061505
• Nikkaji Number: J203.340B
• Wikidata: Q81989505
• Mol file: 1118-15-6.mol

Synonyms:1118-15-6;1,3-Disiloxanediol, 1,1,3,3-tetramethyl-;Tetramethyldisiloxanediol;1,1,3,3-Tetramethyldisiloxane-1,3-diol;1,3-Dihydroxytetramethyldisiloxane;hydroxy-[hydroxy(dimethyl)silyl]oxy-dimethylsilane;Tetramethyl-1,3-disiloxanediol;Tetramethyldisiloxane-1,3-diol;1,1,3,3-Tetramethyl-1,3-dihydroxydisiloxane;EINECS 214-258-9;1,1,3,3-Tetramethyl-1,3-disiloxanediol;1,3-Dihydroxy-1,1,3,3-tetramethyl-1,3-disiloxane;Oxybis(dimethylsilanol);C4H14O3Si2;SCHEMBL119554;DTXSID8061505;C4-H14-O3-Si2;1,3-Disiloxanediol, tetramethyl-;BAA11815;AS-79080;LS-62988;DISILOXANE, 1,3-DIHYDROXYTETRAMETHYL-;1,3-Disiloxanediol, tetramethyl- (6CI,7CI);[(HYDROXYDIMETHYLSILYL)OXY]DIMETHYLSILANOL

Chemical Property of 1,3-Disiloxanediol, 1,1,3,3-tetramethyl-

Chemical Property:

• Vapor Pressure: 0.561mmHg at 25°C
• Melting Point: 65-69 °C
• Refractive Index: 1.425
• Boiling Point: 167.4°Cat760mmHg
• PKA: 13.55±0.53(Predicted)
• Flash Point: 55°C
• PSA: 49.69000
• Density: 0.993g/cm³
• LogP: 0.39120
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.04814737
• Heavy Atom Count: 9
• Complexity: 90

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1,3,3-Tetramethyldisiloxane-1,3-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(O)O[Si](C)(C)O
• Uses: 1,1,3,3-Tetramethyldisiloxane-1,3-diol is a useful building block in the synthesis of various pharmaceuticals.

Technology Process of 1,3-Disiloxanediol, 1,1,3,3-tetramethyl-

There total 17 articles about 1,3-Disiloxanediol, 1,1,3,3-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

dimethylsilicon dichloride (75-78-5,30107-43-8) → tetramethyl-1,3-disiloxanediol (1118-15-6)

Guidance literature:

With water; ammonium carbonate; sodium chloride; In diethyl ether;

DOI:10.1016/0022-328X(94)87098-5

Reference yield: 88.0%

dibenzyloxydimethylsilane (50870-64-9) → dimethylsilanediol (1066-42-8,31900-57-9) + tetramethyl-1,3-disiloxanediol (1118-15-6)

Guidance literature:

With palladium-platinum; hydrogen; aniline; In N,N-dimethyl acetamide; at 20 ℃; for 2h; Concentration;

Reference yield: 63.0%

1,1,3,3-tetramethyl-1,3-dichlorodisiloxane (2401-73-2) → tetramethyl-1,3-disiloxanediol (1118-15-6)

Guidance literature:

With ammonium carbonate; dmap; water; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/0022-328X(93)80320-B

upstream raw materials:

1,1,3,3-tetramethyl-1,3-dichlorodisiloxane

octamethylcyclotetrasiloxane

dimethylsilicon dichloride

methanol

Downstream raw materials:

2-Chloro-4,4,6,6-tetramethyl-2-phenyl-[1,3,5,2,4,6]trioxatrisilinane

2,8-dichloro-2,8-diphenyl-4,4,6,6,10,10,12,12-octamethylcyclohexasiloxane

1,1,3,3,5,5,7,7-octamethyl-1,7-diphenyl-tetrasiloxane

dimethylsilanediol

Refernces

• 1、 Lickiss, Paul D.,Redhouse, Alan D.,Thompson, Robin J.,Stanczyk, Wlodzimierz A.,Rozga, Krystyna. "The crystal structure of (HOMe2Si)2O". . p. 13 - 16. Retrieved 1993.
• 2、 -. "Silanol Compound, Composition, and Method for Producing Silanol Compound". Paragraph 0224-0230. . Retrieved 2017/07/14.
• 3、 Motokura, Ken,Kashiwame, Daiki,Miyaji, Akimitsu,Baba, Toshihide. "Copper-catalyzed formic acid synthesis from CO2 with hydrosilanes and H2O". experimental part. p. 2642 - 2645. Retrieved 2012/08/13.