D-LYSINE METHYL ESTER DIHYDROCHLORIDE

Base Information

• Chemical Name: D-LYSINE METHYL ESTER DIHYDROCHLORIDE
• CAS No.: 67396-08-1
• Molecular Formula: C₇H₁₇N₂O₂*Cl
• Molecular Weight: 196.677
• Mol file: 67396-08-1.mol

Synonyms:methyl (2R)-2,6-diaminohexanoate,dihydrochloride;

Chemical Property of D-LYSINE METHYL ESTER DIHYDROCHLORIDE

Chemical Property:

• Melting Point: 205oC
• Refractive Index: -17 ° (C=5, H2O)
• PSA: 78.34000
• LogP: 2.62030
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98% ^*data from raw suppliers

D-Lysine Methyl Ester Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Lysine Methyl Ester is a protected form of D-Lysine (L468930). D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.

Technology Process of D-LYSINE METHYL ESTER DIHYDROCHLORIDE

There total 18 articles about D-LYSINE METHYL ESTER DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

With thionyl chloride; for 17h; Reflux;

DOI:10.1016/j.tetlet.2015.12.070

Reference yield: 100.0%

methanol (67-56-1) + L-lysine (56-87-1,3506-25-0) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.166667h;

L-lysine; at 0 ℃; for 3.16667h; Reflux;

DOI:10.1016/j.tet.2016.04.084

Reference yield: 99.4%

chloro-trimethyl-silane (75-77-4) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

In methanol;

upstream raw materials:

methanol

L-lysine

L-Lysine hydrochloride

2,2-dimethoxy-propane

Downstream raw materials:

Trt-Lys(Trt)-OMe

C₃₁H₃₄N₂O₄P₂

2-aminocaprolactam

N,O-bis(3,4-dimethoxycarbonylcaffeoyl)-L-lysine methyl ester

Refernces

• 1、 Pandya, Anjali,Patravale, Vandana,Pukale, Sudeep. "Synthesis, characterization and topical application of novel bifunctional peptide metallodendrimer". . . Retrieved 2021/10/30.
• 2、 Yan, Jijun,Kang, Chuanqing,Bian, Zheng,Jin, Rizhe,Ma, Xiaoye,Gao, Lianxun. "Supramolecular self-assembly of chiral polyimides driven by repeat units and end groups". supporting information. p. 14723 - 14729. Retrieved 2017/11/28.