Benzenemethanol, a-methyl-2-nitro-, dihydrogen phosphate (ester)

Base Information

• Chemical Name: Benzenemethanol, a-methyl-2-nitro-, dihydrogen phosphate (ester)
• CAS No.: 67030-24-4
• Molecular Formula: C8H10NO6P
• Molecular Weight: 247.144
• Mol file: 67030-24-4.mol

Synonyms:

Chemical Property of Benzenemethanol, a-methyl-2-nitro-, dihydrogen phosphate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, a-methyl-2-nitro-, dihydrogen phosphate (ester)

There total 4 articles about Benzenemethanol, a-methyl-2-nitro-, dihydrogen phosphate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Phosphoric acid bis-(2-cyano-ethyl) ester 1-(2-nitro-phenyl)-ethyl ester (144758-79-2) → 1-(2-Nitrophenyl)ethyl dihydrogen phosphate (67030-24-4)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 0.5h;

DOI:10.1039/c8sc01233d

Reference yield:

1-(2-nitrophenyl)ethan-1-ol (80379-10-8,108530-03-6,142631-59-2,3205-25-2) → 1-(2-Nitrophenyl)ethyl dihydrogen phosphate (67030-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole / acetonitrile / 20 °C

2: tert.-butylhydroperoxide / 1 h / -40 °C

3: sodium hydroxide / methanol / 0.5 h / 50 °C

With 1H-tetrazole; tert.-butylhydroperoxide; sodium hydroxide; In methanol; acetonitrile;

DOI:10.1039/c8sc01233d

Reference yield:

C14H16N3O5P → 1-(2-Nitrophenyl)ethyl dihydrogen phosphate (67030-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylhydroperoxide / 1 h / -40 °C

2: sodium hydroxide / methanol / 0.5 h / 50 °C

With tert.-butylhydroperoxide; sodium hydroxide; In methanol;

DOI:10.1039/c8sc01233d

upstream raw materials:

1-(2-nitrophenyl)ethan-1-ol

Phosphoric acid bis-(2-cyano-ethyl) ester 1-(2-nitro-phenyl)-ethyl ester

Refernces

• 1、 Corrie, John E. T.,Trentham, David R.. "Synthetic, Mechanistic and Photochemical Studies of Phosphate Esters of Substituted Benzoins". . p. 2409 - 2418. Retrieved 2007/10/02.