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(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Base Information Edit
  • Chemical Name:(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • CAS No.:53-85-0
  • Molecular Formula:C12H12Cl2N2O4
  • Molecular Weight:319.144
  • Hs Code.:29349990
  • NSC Number:401575
  • ChEMBL ID:CHEMBL267071
  • Mol file:53-85-0.mol
(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Synonyms:(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;MLS003171503;2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;DRB;C12-H12-Cl2-N2-O4;NSC401575;NSC-401575;Kinome_3639;CHEMBL267071;SCHEMBL20419020;SCHEMBL23982247;HMS3373F12;NCGC00096104-01;NCGC00096104-02;SMR001875388;FT-0666623;5,6-dichloro-1-beta-d-ribofuranosylbenzimi-dazole;Benzimidazole,6-dichloro-1-.beta.-D-ribofuranosyl-;1H-Benzimidazole,6-dichloro-1-.beta.-D-ribofuranosyl-;Dichlorobenzimidazole Riboside, DRB (5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole)

Suppliers and Price of (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • 5,6-Dichloropurine-1-b-D-ribofuanosyl-H-benzimidazole
  • 100mg
  • $ 460.00
  • Usbiological
  • 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside
  • 25mg
  • $ 347.00
  • TRC
  • 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
  • 10mg
  • $ 55.00
  • TRC
  • 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
  • 100mg
  • $ 185.00
  • TRC
  • 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
  • 250mg
  • $ 350.00
  • TCI Chemical
  • 5,6-Dichlorobenzimidazole 1-beta-D-Ribofuranoside >98.0%(HPLC)(N)
  • 1g
  • $ 905.00
  • TCI Chemical
  • 5,6-Dichlorobenzimidazole 1-beta-D-Ribofuranoside >98.0%(HPLC)(N)
  • 100mg
  • $ 154.00
  • Sigma-Aldrich
  • 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
  • 50mg
  • $ 147.00
  • Sigma-Aldrich
  • 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
  • 50mg
  • $ 129.50
  • Sigma-Aldrich
  • 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
  • 10mg
  • $ 55.50
Total 31 raw suppliers
Chemical Property of (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol Edit
Chemical Property:
  • Appearance/Colour:White to off-white crystalline solid. 
  • Vapor Pressure:1.51E-15mmHg at 25°C 
  • Melting Point:222-224°C 
  • Refractive Index:1.6200 (estimate) 
  • Boiling Point:606.2 °C at 760 mmHg 
  • PKA:13.23±0.70(Predicted) 
  • Flash Point:320.4 °C 
  • PSA:87.74000 
  • Density:1.84 g/cm3 
  • LogP:0.95460 
  • Storage Temp.:−20°C 
  • Solubility.:Soluble in DMSO (up to 20 mg/ml) 
  • Water Solubility.:Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer 
  • XLogP3:1.1
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:2
  • Exact Mass:318.0174123
  • Heavy Atom Count:20
  • Complexity:364
Purity/Quality:

98%,99%, *data from raw suppliers

5,6-Dichloropurine-1-b-D-ribofuanosyl-H-benzimidazole *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:C1=C2C(=CC(=C1Cl)Cl)N(C=N2)C3C(C(C(O3)CO)O)O
  • Description DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II.?A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2?Also inhibits casein kinase II, IC50=4-10 μM.?3?Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4?Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
  • Uses DRB is an inhibitor of RNA synthesis (causes premature termination of transcription). Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases. 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:as an inhibitor of RNA polymerase II in mouse melanoma cellsfor the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell linesin the inhibition of interleukin-2 gene transcription in Jurkat cells
Technology Process of (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol

There total 16 articles about (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With nickel; In ethanol; for 8h; Heating;
DOI:10.1021/jm00044a015
Guidance literature:
for 3h; purine nucleoside phosphorylase of whole cells of E. coli BMT 1D/1A;
DOI:10.1080/15257779508012409
Guidance literature:
With potassium carbonate; In methanol; water; at 20 ℃; for 0.333333h;
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