C(11)-Methyl-hexahydrocannabinol

Base Information

• Chemical Name: C(11)-Methyl-hexahydrocannabinol
• CAS No.: 6692-85-9
• Molecular Formula: C21H32O2
• Molecular Weight: 0
• Mol file: 6692-85-9.mol

Synonyms:C(11)-methyl-hexahydrocannabinol

Chemical Property of C(11)-Methyl-hexahydrocannabinol

Chemical Property:

• PSA: 29.46000
• LogP: 5.81570

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C(11)-Methyl-hexahydrocannabinol

There total 10 articles about C(11)-Methyl-hexahydrocannabinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3,7-dimethyl-oct-6-enal (106-23-0,26489-02-1) + Olivetol (500-66-3) → Hexahydrocannabinol (1972-09-4,6692-85-9)

Guidance literature:

With quinoline; for 24h; Heating;

Reference yield:

2-[1-(3,7-Dimethyl-oct-6-enylsulfanyl)-3,7-dimethyl-oct-6-enyl]-5-pentyl-benzene-1,3-diol → 3-Hydroxy-5-pentyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-dibenzopyran (1972-09-4,6692-85-9,23050-51-3,23050-52-4,36403-90-4,36403-91-5,58617-32-6,58617-33-7,59042-47-6,69855-11-4,69855-12-5,69855-14-7,69880-65-5,103476-58-0,146338-70-7)

Guidance literature:

With boron trifluoride diethyl etherate; In benzene; for 2h; Yield given; Ambient temperature;

DOI:10.1246/bcsj.63.1647

Reference yield:

di(3,7-dimethyl-6-octenyl)sulfide (128936-94-7) → 3-Hydroxy-5-pentyl-6,6,9-trimethyl-6a,7,8,9,10,10a-hexahydro-6H-dibenzopyran (1972-09-4,6692-85-9,23050-51-3,23050-52-4,36403-90-4,36403-91-5,58617-32-6,58617-33-7,59042-47-6,69855-11-4,69855-12-5,69855-14-7,69880-65-5,103476-58-0,146338-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) SO₂Cl₂/Py, 2) NEt₃ / 1) CH₂Cl₂, 2) C₆H₁₂

2: sodium borohydride / diethyl ether / 18 h / 50 °C

3: BF₃*OEt₂ / benzene / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; sulfuryl dichloride; boron trifluoride diethyl etherate; triethylamine; In diethyl ether; benzene;

DOI:10.1246/bcsj.63.1647

upstream raw materials:

3,7-dimethyl-oct-6-enal

Olivetol

di(3,7-dimethyl-6-octenyl)sulfide

olivetol monoacetate

Refernces

• 1、 Inoue,Inoue,Sato. "Lewis acid catalyzed reaction of o-[1-(alkylthio)alkyl]phenols: The generation and reaction of o-quinonemethides and applications to cannabinoid synthesis". . p. 1647 - 1652. Retrieved 2007/10/02.