L-Homoserine lactone hydrochloride

Base Information

• Chemical Name: L-Homoserine lactone hydrochloride
• CAS No.: 2185-03-7
• Molecular Formula: C4H7NO2^.HCl
• Molecular Weight: 137.566
• Hs Code.: 29322090
• European Community (EC) Number: 218-571-1
• Mol file: 2185-03-7.mol

Synonyms:2185-03-7;L-Homoserine lactone hydrochloride;L-Homoserine lactone HCl;(S)-3-Aminodihydrofuran-2(3H)-one hydrochloride;(S)-Homoserine-lactone hydrochloride;L-Homoserine Lactone, Hydrochloride;(S)-(-)-3-Aminotetrahydrofuran-2-one Hydrochloride;(3S)-3-aminooxolan-2-one hydrochloride;L-Homoserine lactone, HCl;MFCD00058172;(3S)-3-aminooxolan-2-one;hydrochloride;2(3H)-Furanone, 3-aminodihydro-, hydrochloride, (3S)-;L-Homoserine lactone hydrochlide;L-Homoserinelactonehydrochloride;(3S)-3-Aminotetrahydrofuran-2-one hydrochloride;(S)-alpha-Amino-gamma-butyrolactone hydrochloride;(S)-(+)- |A-amino-|A-butyrolactone hydrochloride;SCHEMBL787339;XBKCXPRYTLOQKS-DFWYDOINSA-N;BCP20062;L-Homoserine Lactone hydrochloride?;FD1139;L-Homoserine lactone (hydrochloride);AKOS005146324;AC-5669;CS-W016516;GS-3428;L-(-)-Homoserine Lactone Hydrochloride;(s)-2-amino4-butyrolactone hydrochloride;(s)-2-amino-4-butyrolactone hydrochloride;(S)-a-Amino-?-butyrolactone hydrochloride;AM20090203;EN300-262476;(S)-3-Amino-dihydrofuran-2(3H)-one hydrochloride;J-014314;(S)-(-)-alpha-Amino-gamma-butyrolactone Hydrochloride;(S)-alpha-Amino-gamma-butyrolactone hydrochloride, 97%;L-Homoserine lactone,(S)-2-amino-4-butyrolactone hydrochloride

Chemical Property of L-Homoserine lactone hydrochloride

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.000411mmHg at 25°C
• Melting Point: 221-226 °C
• Refractive Index: -26 ° (C=0.2, H2O)
• Boiling Point: 257.1 °C at 760 mmHg
• Flash Point: 120.1 °C
• PSA: 52.32000
• LogP: 0.76290
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 137.0243562
• Heavy Atom Count: 8
• Complexity: 91.7

Purity/Quality:

96% ^*data from raw suppliers

L-Homoserine Lactone, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=O)C1N.Cl
• Isomeric SMILES: C1COC(=O)[C@H]1N.Cl
• Uses: (S)-α-Amino-γ-butyrolactone hydrochloride can be used:As a precursor for the preparation of amino-keto-alcohols and β-amino acids.To prepare N-acylhomoserine lactone (AHL) analogs by reacting with substituted 2-chloro-N-phenylacetamide and different halides.As a starting material for the synthesis of L-discadenine.

Technology Process of L-Homoserine lactone hydrochloride

There total 19 articles about L-Homoserine lactone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-N-(2-oxo-tetrahydrofuran-3-yl)-2-phenylacetamide (55154-48-8) → L-homoserine lactone hydrochloride (2185-03-7)

Guidance literature:

With hydrogenchloride; water; for 6h; Reflux;

DOI:10.1016/j.tetasy.2011.10.015

Reference yield: 99.0%

L-homoserine (672-15-1,119736-88-8) → L-homoserine lactone hydrochloride (2185-03-7)

Guidance literature:

With hydrogenchloride; In water; for 0.25h;

Reference yield: 97.0%

(S)-N-tritylhomoserine lactone (83427-81-0) → L-homoserine lactone hydrochloride (2185-03-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85851-8

upstream raw materials:

(S)-N-trifluoroacetylaspartic acid-1-methyl ester

L-homoserine

L-Aspartic acid

(S)-2-hydroxyimino-3-(N-tritylamino)oxolane

Downstream raw materials:

4-butanolide

Seleno-L-methionine

N-acetyl-DL-homocysteinethiolactone

Refernces

• 1、 -. "L-GLUFOSINATE INTERMEDIATE AND L-GLUFOSINATE PREPARATION METHOD". Paragraph 0160-0162. . Retrieved 2022/02/05.
• 2、 Hossain, Mohammad Anwar,Sattenapally, Narsimha,Parikh, Hardik I.,Li, Wei,Rumbaugh, Kendra P.,German, Nadezhda A.. "Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence". supporting information. . Retrieved 2019/11/26.