Pyrrolidine, 1-(phenylmethoxy)-

Base Information

• Chemical Name: Pyrrolidine, 1-(phenylmethoxy)-
• CAS No.: 46235-83-0
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 46235-83-0.mol

Synonyms:

Chemical Property of Pyrrolidine, 1-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-(phenylmethoxy)-

There total 2 articles about Pyrrolidine, 1-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4--N-(benzyloxy)amino>-1-butyl bromide (94136-42-2) → 1-Benzyloxy-pyrrolidine (46235-83-0)

Guidance literature:

With acetic acid; zinc; for 0.75h; Ambient temperature;

DOI:10.1021/jm00381a011

Reference yield:

N-<(2,2,2-trichloroethoxy)carbonyl>-O-benzylhydroxylamine (90195-00-9) → 1-Benzyloxy-pyrrolidine (46235-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature

2: 85 percent / Zn, acetic acid / 0.75 h / Ambient temperature

With sodium hydride; acetic acid; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jm00381a011

Reference yield: 82.0%

1-Benzyloxy-pyrrolidine (46235-83-0) + Diphenylphosphine oxide (4559-70-0) → diphenyl(pyrrolidin-1-yl)phosphine oxide

Guidance literature:

With potassium carbonate; In tert-Amyl alcohol; at 105 ℃; for 8h;

DOI:10.1021/acs.orglett.5b03056

upstream raw materials:

4--N-(benzyloxy)amino>-1-butyl bromide

N-<(2,2,2-trichloroethoxy)carbonyl>-O-benzylhydroxylamine

Refernces