2-Bromo-1-(2-bromophenyl)ethanone

Base Information

• Chemical Name: 2-Bromo-1-(2-bromophenyl)ethanone
• CAS No.: 49851-55-0
• Molecular Formula: C8H6Br2O
• Molecular Weight: 277.943
• Hs Code.: 2914700090
• European Community (EC) Number: 689-312-1
• DSSTox Substance ID: DTXSID10372109
• Wikidata: Q72448986
• Mol file: 49851-55-0.mol

Synonyms:2-bromo-1-(2-bromophenyl)ethanone;49851-55-0;2-Bromophenacyl bromide;2-Bromo-1-(2-bromophenyl)ethan-1-one;2,2'-Dibromoacetophenone;2-Bromo-1-(2-bromo-phenyl)-ethanone;MFCD00044660;2-Bromo-2'-bromoacetophenone;bromphenacyl bromide;SCHEMBL166468;DTXSID10372109;LAXPJIJQTHJGCK-UHFFFAOYSA-N;CK2304;2-bromo-1-(2-bromophenyl)-ethanone;AKOS000122305;AS-45881;SY041192;B4124;CS-0181796;FT-0649682;EN300-01887;2,2 inverted exclamation mark -Dibromoacetophenone;A827879

Chemical Property of 2-Bromo-1-(2-bromophenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 299.9 °C at 760 mmHg
• Flash Point: 108.1 °C
• PSA: 17.07000
• Density: 1.848 g/cm³
• LogP: 3.02670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Lachrymatory
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 277.87649
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

98% ^*data from raw suppliers

2,2''-Dibromoacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)CBr)Br
• Uses: 2,2''-Dibromoacetophenone is used in the preparation of 4-phenylthiazol-2(3H)-one derivatives as anticonvulsant agents.

Technology Process of 2-Bromo-1-(2-bromophenyl)ethanone

There total 15 articles about 2-Bromo-1-(2-bromophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromophenyl methyl ketone (2142-69-0) → 2,2'-dibromoacetophenone (49851-55-0)

Guidance literature:

With bromine; In diethyl ether; at 20 ℃; for 2h;

Reference yield: 82.0%

1-(bromoethynyl)-2-bromobenzene (401514-46-3) → 2,2'-dibromoacetophenone (49851-55-0)

Guidance literature:

With water; copper(II) acetate monohydrate; trifluoroacetic acid; at 70 ℃; for 6h; chemoselective reaction;

DOI:10.1002/ejoc.201501198

Reference yield: 80.0%

2-bromo-ω-diazoacetophenone (46004-44-8) → 2,2'-dibromoacetophenone (49851-55-0)

Guidance literature:

With ferric(III) bromide; silica gel; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2018.02.024

upstream raw materials:

2-bromophenyl methyl ketone

2-bromo-ω-diazoacetophenone

2-bromobenzoic acid chloride

o-cyanobromobenzene

Downstream raw materials:

4-Amino-1-[2-(2-bromo-phenyl)-2-oxo-ethyl]-4H-[1,2,4]triazol-1-ium; bromide

1-(2-bromo phenyl)-2-phenoxy etanone

benzofuran-2-yl(2-bromophenyl)methanone

4-(2-Bromo-phenyl)-2-methyl-5-nitro-oxazole

Refernces

• 1、 Mishra, Ashish A.,Bhanage, Bhalchandra M.. "Ru-Tethered (R,R)-TsDPEN with DMAB as an efficient catalytic system for high enantioselective one-pot synthesis of chiral β-aminolviaasymmetric transfer hydrogenation". supporting information. p. 5357 - 5362. Retrieved 2021/04/06.
• 2、 Cheng, Zhao,Guo, Hongmei,Huang, Guozheng,Rexit, Abulikemu Abudu,Wang, Hui,Zheng, Meng-Xia. "Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System". supporting information. p. 6455 - 6458. Retrieved 2020/10/21.