Methyl N-acetyl-2-methylalaninate

Base Information

• Chemical Name: Methyl N-acetyl-2-methylalaninate
• CAS No.: 43135-06-4
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18
• Mol file: 43135-06-4.mol

Synonyms:

Chemical Property of Methyl N-acetyl-2-methylalaninate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Methyl N-acetyl-2-methylalaninate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl N-acetyl-2-methylalaninate

There total 3 articles about Methyl N-acetyl-2-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-amino-2-methylpropionic acid methyl ester (13257-67-5) + acetic anhydride (108-24-7) → Ac-Aib-OMe (43135-06-4)

Guidance literature:

DOI:10.1016/0040-4020(82)85164-8

Reference yield: 47.0%

methanol (67-56-1) + N-acetyl-α,α-dimethylglycine (5362-00-5) → Ac-Aib-OMe (43135-06-4)

Guidance literature:

With thionyl chloride; at 0 ℃; for 4h;

DOI:10.1021/acs.joc.8b03224

Reference yield: 42.0%

methyl 2-aminoisobutyrate hydrochloride (15028-41-8) + acetyl chloride (75-36-5) → Ac-Aib-OMe (43135-06-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.3998/ark.5550190.p008.622

upstream raw materials:

methyl 2-aminoisobutyrate hydrochloride

acetyl chloride

2-amino-2-methylpropionic acid methyl ester

acetic anhydride

Refernces

• 1、 Monteiro, Luis S.,Pereira-Lima, Silvia M.M.A.,Pereira, Sofia,Machado, Joao N.. "Synthesis of N-alkyl-Cα,α-dimethylglycine derivatives". . p. 170 - 180. Retrieved 2014/10/15.