N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE

Base Information

• Chemical Name: N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE
• CAS No.: 6319-45-5
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2935009090
• Mol file: 6319-45-5.mol

Synonyms:Benzenesulfonamide,N-methyl-p-nitro- (6CI,8CI);4-Nitrobenzenesulfonic acid methylamide;N-Methyl-4-nitrobenzenesulfonamide;N-Methyl-p-nitrobenzenesulfonamide;NSC31052;

Chemical Property of N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE

Chemical Property:

• Vapor Pressure: 6.6E-06mmHg at 25°C
• Melting Point: 105-106 °C
• Refractive Index: 1.57
• Boiling Point: 377.7 °C at 760 mmHg
• PKA: 10.31±0.30(Predicted)
• Flash Point: 182.3 °C
• PSA: 100.37000
• Density: 1.423 g/cm³
• LogP: 2.49780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-4-nitrobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE

There total 18 articles about N1-METHYL-4-NITROBENZENE-1-SULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methylamine (74-89-5) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-methyl-4-nitro-benzenesulfonamide (6319-45-5)

Guidance literature:

In diethyl ether; water; for 16h; Ambient temperature;

DOI:10.1021/jm970036a

Reference yield: 98.0%

4-Nitrobenzenesulfonyl chloride (98-74-8) → N-methyl-4-nitro-benzenesulfonamide (6319-45-5)

Guidance literature:

With methylamine; In dichloromethane;

Reference yield: 92.0%

N-benzyl-N-methyl-4-nitrobenzenesulfonamide → N-methyl-4-nitro-benzenesulfonamide (6319-45-5)

Guidance literature:

With Oxone; potassium bromide; In nitromethane; at 50 ℃; for 24h; Green chemistry;

DOI:10.1021/ol501703y

upstream raw materials:

methylamine

4-Nitrobenzenesulfonyl chloride

C₇H₇N₃O₆S

4-nitro-benzenesulfonic acid-(methyl-nitroso-amide)

Downstream raw materials:

N-methyl-4-aminobenzenesulfonamide

N-methyl-N-phenyl-4-nitrobenzene sulphonamide

4-(N,N-dimethylaminosulfonyl)nitrobenzene

N-{2-[3-bromo-4-hydroxy-5-(trimethylsilyl)phenyl]ethyl}-N-methyl-4-nitrobenzenesulfonamide

Refernces

• 1、 Engl, Sebastian,Reiser, Oliver. "Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications". supporting information. p. 5581 - 5586. Retrieved 2021/07/26.
• 2、 Liu, Peng,Tung, Nguyen Thanh,Xu, Xiangchao,Yang, Jiazhi,Li, Feng. "N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]". . p. 2621 - 2631. Retrieved 2021/02/27.