N-cyclohexyl-N-methylcarbamoyl chloride

Base Information

• Chemical Name: N-cyclohexyl-N-methylcarbamoyl chloride
• CAS No.: 35028-38-7
• Molecular Formula: C8H14ClNO
• Molecular Weight: 175.658
• European Community (EC) Number: 871-506-4
• Mol file: 35028-38-7.mol

Synonyms:N-cyclohexyl-N-methylcarbamoyl chloride;35028-38-7;N-methyl-N-cyclohexylaminocarbonyl chloride;SCHEMBL427210;BZWYKPFEWYJQJZ-UHFFFAOYSA-N;cyclohexyl(methyl)carbamic chloride;N-cyclohexyl-N-methylcarbamoylchloride;AKOS016359857;N-methyl-N-cyclohexylcarbamoyl chloride;N-cyclohexyl-N-methyl carbamoyl chloride;EN300-187690;G48205

Chemical Property of N-cyclohexyl-N-methylcarbamoyl chloride

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 175.0763918
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C1CCCCC1)C(=O)Cl

Technology Process of N-cyclohexyl-N-methylcarbamoyl chloride

There total 2 articles about N-cyclohexyl-N-methylcarbamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-methylcyclohexylamine (100-60-7) + bis(trichloromethyl) carbonate (32315-10-9) → N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7)

Guidance literature:

With pyridine; In toluene;

DOI:10.1016/S0960-894X(98)00246-7

Reference yield:

phosgene (75-44-5) + N-methylcyclohexylamine (100-60-7) → N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7)

Guidance literature:

With triethylamine; In toluene; Heating;

Reference yield: 92.0%

3-(1H-imidazol-4-yl)pyridine (51746-85-1) + N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7) → N-cyclohexyl-N-methyl-4-(pyridin-3-yl)-1H-imidazole-1-carboxamide (1233855-18-9)

Guidance literature:

With pyridine; In dichloromethane; at 25 - 90 ℃; Temperature; Time; Solvent; Reagent/catalyst; Concentration;

upstream raw materials:

phosgene

N-methylcyclohexylamine

bis(trichloromethyl) carbonate

Downstream raw materials:

Cyclohexyl-methyl-carbamic acid 2,5-dimethyl-4-methylsulfanyl-phenyl ester

cyclohexyl-methyl-carbamic acid 3-(2-tert-butoxycarbonylamino-propyl)-phenyl ester

cyclohexyl-methyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Refernces

• 1、 Patel, Jayendra Z.,Nevalainen, Tapio J.,Savinainen, Juha R.,Adams, Yahaya,Laitinen, Tuomo,Runyon, Robert S.,Vaara, Miia,Ahenkorah, Stephen,Kaczor, Agnieszka A.,Navia-Paldanius, Dina,Gynther, Mikko,Aaltonen, Niina,Joharapurkar, Amit A.,Jain, Mukul R.,Haka, Abigail S.,Maxfield, Frederick R.,Laitinen, Jarmo T.,Parkkari, Teija. "Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors". . p. 253 - 265. Retrieved 2015/02/05.
• 2、 Ortar, Giorgio,Morera, Enrico,De Petrocellis, Luciano,Ligresti, Alessia,Schiano Moriello, Aniello,Morera, Ludovica,Nalli, Marianna,Ragno, Rino,Pirolli, Adele,Di Marzo, Vincenzo. "Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring". . p. 118 - 132. Retrieved 2013/07/27.