2-Methyl-3-phenylquinazolin-4-one

Base Information

• Chemical Name: 2-Methyl-3-phenylquinazolin-4-one
• CAS No.: 2385-23-1
• Molecular Formula: C15H12 N2 O
• Molecular Weight: 236.273
• Hs Code.: 2933990090
• European Community (EC) Number: 653-515-3
• NSC Number: 632914,37229
• UNII: MZ50P7I69J
• DSSTox Substance ID: DTXSID00178551
• Nikkaji Number: J479.423K
• Wikidata: Q83048998
• ChEMBL ID: CHEMBL2261964
• Mol file: 2385-23-1.mol

Synonyms:2385-23-1;2-Methyl-3-phenylquinazolin-4-one;2-Methyl-3-phenyl-4-quinazolone;2-Methyl-3-phenyl-4(3H)-quinazolinone;4(3H)-Quinazolinone, 2-methyl-3-phenyl-;2-methyl-3-phenylquinazolin-4(3H)-one;2-Methyl-3-phenyl-3,4-dihydroquinazolin-4-one;2-methyl-3-phenyl-quinazolin-4-one;NSC 37229;BRN 0181249;2-Methyl-3-phenyl-3H-quinazolin-4-one;MZ50P7I69J;3-Phenyl-2-methylquinazolin-4-one;NSC-37229;NSC632914;NSC-632914;NSC37229;Maybridge3_000475;UNII-MZ50P7I69J;SCHEMBL1682746;CHEMBL2261964;DTXSID00178551;HMS1432F13;STL304752;AKOS000540991;CCG-235972;IDI1_011862;3-Phenyl-2-methylquinazoline-4(3H)-one;LS-141084;CS-0237146;EN300-17853;SR-01000396835;SR-01000396835-1;Z57048969

Chemical Property of 2-Methyl-3-phenylquinazolin-4-one

Chemical Property:

• Vapor Pressure: 1.74E-06mmHg at 25°C
• Boiling Point: 396.2°Cat760mmHg
• Flash Point: 193.4°C
• PSA: 34.89000
• Density: 1.17g/cm³
• LogP: 2.69410
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 236.094963011
• Heavy Atom Count: 18
• Complexity: 358

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3

Technology Process of 2-Methyl-3-phenylquinazolin-4-one

There total 57 articles about 2-Methyl-3-phenylquinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Triethyl orthoacetate (78-39-7) + 2-aminobenzanilide (4424-17-3) → 2-Methyl-3-phenyl-4(3H)-quinazolinone (2385-23-1)

Guidance literature:

With acetic acid; In ethanol; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.3390/molecules23112925

Reference yield: 94.0%

lithium dimethylcuprate (15681-48-8) + 1-phenyl-3-(2-ethoxycarbonylphenyl) carbodiimide (622403-42-3) → 2-Methyl-3-phenyl-4(3H)-quinazolinone (2385-23-1)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 2.5h; Time; Concentration;

DOI:10.1055/s-0032-1316773

Reference yield: 92.0%

acetic anhydride (108-24-7) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + aniline (62-53-3) → 2-Methyl-3-phenyl-4(3H)-quinazolinone (2385-23-1)

Guidance literature:

With titanium dioxide nanoparticles; at 80 ℃; for 5h; Neat (no solvent);

DOI:10.1055/s-0031-1290610

upstream raw materials:

isatoic anhydride

N,N'-diphenylacetamidine

aniline

toluene

Downstream raw materials:

2-methyl-4,4-diphenyl-4H-benzo[d][1,3]oxazine

2-[2-Oxo-2-(2-pyridyl)ethyl]-3-phenyl-4(3H)-quinazolinone

2-[(2,4-Dimethyl-benzylamino)-methyl]-3-phenyl-3H-quinazolin-4-one

2-[(2,4-Dichloro-benzylamino)-methyl]-3-phenyl-3H-quinazolin-4-one

Refernces

• 1、 Sridhar, Radhakrishnan,Takei, Hisashi,Syed, Riyaz,Kobayashi, Ikei S.,Hui, Liu Bee,Kamal, Ahmed,Tenen, Daniel G.,Kobayashi, Susumu S.. "Styryl quinazolinones as potential inducers of myeloid differentiation via upregulation of C/EBPα". . . Retrieved 2018.
• 2、 Foroughifar, Naser,Khajeh-Amiri, Alireza,Norouzi, Fateme Haji,Pasdar, Hoda. "A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media". . p. 29948 - 29959. Retrieved 2021/10/20.
• 3、 Komar, Mario,Konjarevi?, Anastazija,Molnar, Maja. "Screening of natural deep eutectic solvents for green synthesis of 2-methyl-3-substituted quinazolinones and microwave-assisted synthesis of 3-aryl quinazolinones in ethanol". . . Retrieved 2020/07/13.