1-Aminopiperidine

Base Information

• Chemical Name: 1-Aminopiperidine
• CAS No.: 2213-43-6
• Molecular Formula: C5H12N2
• Molecular Weight: 100.164
• Hs Code.: 29339900
• European Community (EC) Number: 218-666-8
• NSC Number: 83225
• UNII: V8G2P7UJ71
• DSSTox Substance ID: DTXSID60176654
• Nikkaji Number: J47.761C
• Wikidata: Q63409555
• Mol file: 2213-43-6.mol

Synonyms:N-aminopiperidine

Chemical Property of 1-Aminopiperidine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 4.53mmHg at 25°C
• Refractive Index: n20/D 1.475(lit.)
• Boiling Point: 146.9 °C at 760 mmHg
• PKA: 8.19±0.20(Predicted)
• Flash Point: 36.1 °C
• PSA: 29.26000
• Density: 0.953 g/cm³
• LogP: 0.98420
• Storage Temp.: Flammables area
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 100.100048391
• Heavy Atom Count: 7
• Complexity: 48

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Aminopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xi
• Hazard Codes: Xi,C
• Statements: 10-36/37/38-34-20/21/22-36/37/39
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Cyclic
• Canonical SMILES: C1CCN(CC1)N
• Uses: Reactant for synthesis of:? ;CB1 cannabinoid receptor ligands1?? ;Hydrazones2?? ;Tetrahydronaphthalene derivatives affecting proliferation and nitric oxide production in LPS activated RAW 264.7 macrophages3? ;Phosphorus(V) hydrazines4 Reactant for synthesis of:CB1 cannabinoid receptor ligands?Hydrazones?Tetrahydronaphthalene derivatives affecting proliferation and nitric oxide production in LPS activated RAW 264.7 macrophagesPhosphorus(V) hydrazines

Technology Process of 1-Aminopiperidine

There total 31 articles about 1-Aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

piperidine (110-89-4) → 1-Aminopiperidine (2213-43-6)

Guidance literature:

With sodium hydroxide; hydroxylamine-O-sulfonic acid; In water; at 20 ℃; pH=11 - 12; Temperature; Concentration; Kinetics;

DOI:10.1134/S0023158412010041

Reference yield: 95.0%

N-nitrosopiperidine (100-75-4) → 1-Aminopiperidine (2213-43-6)

Guidance literature:

With zinc; In acetic acid;

DOI:10.1007/BF00766687

Reference yield: 93.0%

2-piperidin-1-ylbenzo[de]isoquinoline-1,3-dione → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + 1-Aminopiperidine (2213-43-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

piperidine

N-nitrosopiperidine

N-nitropiperidine

1-piperidinecarboxamide

Downstream raw materials:

1-pyrrolidin-1-yl-piperidine

1-(4-chloro-benzylidenamino)-piperidine

4-nitrobenzaldehyde-N,N-pentamethylene hydrazone

benzaldehyde-N,N-pentamethylene hydrazone

Refernces

• 1、 Darwich,Elkhatib,Pasquet,Delalu. "Kinetic and mechanistic study of N-aminopiperidine formation via the raschig process". . p. 649 - 655. Retrieved 2013.
• 2、 Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah. "N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides". supporting information. p. 17713 - 17721. Retrieved 2021/11/10.
• 3、 Wu, Yachuang,Ding, Xiudong,Ding, Liang,Zhang, Yongsheng,Cui, Lei,Sun, Lu,Li, Wei,Wang, Di,Zhao, Yanfang. "Synthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents". . p. 247 - 258. Retrieved 2018/09/18.