Benzeneacetic acid, a-[(trifluoroacetyl)amino]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-[(trifluoroacetyl)amino]-, 1,1-dimethylethyl ester
• CAS No.: 188591-75-5
• Molecular Formula: C14H16F3NO3
• Molecular Weight: 303.281
• Mol file: 188591-75-5.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-[(trifluoroacetyl)amino]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-[(trifluoroacetyl)amino]-, 1,1-dimethylethyl ester

There total 1 articles about Benzeneacetic acid, a-[(trifluoroacetyl)amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,2,2-trifluoroacetamide (354-38-1) + tert-butyl α-bromo-α-phenylacetate (35132-16-2) → Phenyl-(2,2,2-trifluoro-acetylamino)-acetic acid tert-butyl ester (188591-75-5)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; at 25 - 80 ℃; for 24h;

Reference yield:

Phenyl-(2,2,2-trifluoro-acetylamino)-acetic acid tert-butyl ester (188591-75-5) → 2-aminophenylacetic acid tert-butyl ester (53934-78-4,65715-93-7,67672-72-4,124619-74-5) + phenylglycin (2835-06-5)

Guidance literature:

With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 25 ℃; for 168h; Yield given. Yields of byproduct given;

upstream raw materials:

2,2,2-trifluoroacetamide

tert-butyl α-bromo-α-phenylacetate

Downstream raw materials:

2-aminophenylacetic acid tert-butyl ester

phenylglycin

Refernces