N-(4-NITROPHENYL)FORMAMIDE 97

Base Information

• Chemical Name: N-(4-NITROPHENYL)FORMAMIDE 97
• CAS No.: 16135-31-2
• Molecular Formula: C7H6 N2 O3
• Molecular Weight: 166.136
• Hs Code.: 2924299090
• Mol file: 16135-31-2.mol

Synonyms:Formanilide,4-nitro- (7CI); Formanilide, 4'-nitro- (8CI); 4'-Nitroformanilide;N-(4-Nitrophenyl)formamide; N-(p-Nitrophenyl)formamide;N-Formyl-4-nitroaniline; N-Formyl-p-nitroaniline; NSC 25178;p-(Formylamino)nitrobenzene; p-Nitroformanilide; p-Nitrophenylformamide

Chemical Property of N-(4-NITROPHENYL)FORMAMIDE 97

Chemical Property:

• Vapor Pressure: 1.84E-06mmHg at 25°C
• Melting Point: 196-200 °C(lit.)
• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 193°C
• PSA: 74.92000
• Density: 1.407g/cm³
• LogP: 2.39520

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Nitrophenyl)formamide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-(4-NITROPHENYL)FORMAMIDE 97

There total 57 articles about N-(4-NITROPHENYL)FORMAMIDE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formic acid (64-18-6) + 4-nitro-aniline (100-01-6,104810-17-5) → p-nitroformanilide (16135-31-2)

Guidance literature:

With nano-MgO; for 0.0166667h; Microwave irradiation;

DOI:10.1007/s10562-010-0372-6

Reference yield: 94.0%

hexanal (66-25-1) + 4-nitro-aniline (100-01-6,104810-17-5) → p-nitroformanilide (16135-31-2)

Guidance literature:

With oxygen; manganese(III) triacetate dihydrate; In toluene; at 90 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/ol300781s

Reference yield: 92.0%

4-chlorophenyl formate (1988-22-3) + 4-nitro-aniline (100-01-6,104810-17-5) → p-nitroformanilide (16135-31-2)

Guidance literature:

In neat (no solvent); at 20 ℃; for 12h;

DOI:10.1080/00397911.2016.1255334

upstream raw materials:

pyridine

formic acid

4-nitro-aniline

Formanilid

Downstream raw materials:

N¹,N²-di(p-nitrophenyl)formamidine

4-nitrophenylisocyanide dichloride

p-nitrophenyl isocyanide

ethyl 4-nitrophenylcarbamate

Refernces

• 1、 Fastrez,Fersht. "Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships.". . p. 1067,1069, 1072. Retrieved 1973.
• 2、 Zeller, Matthias,Hunter, Allen D.. "p-Nitrophenyl isocyanide". . p. o415-o417. Retrieved 2004.
• 3、 Szczepankiewicz,Suwinski. "One-pot synthesis of 3-(2-cyanophenyl)quinazolin-4(3h)-one". . p. 809 - 810. Retrieved 2000.
• 4、 Amirsoleimani, Mina,Khalilzadeh, Mohammad A.,Zareyee, Daryoush. "Preparation and catalytic evaluation of a palladium catalyst deposited over modified clinoptilolite (Pd&at;MCP) for chemoselective N-formylation and N-acylation of amines". . . Retrieved 2020/08/22.
• 5、 Zhao, Xue Zhi,Kiselev, Evgeny,Lountos, George T.,Wang, Wenjie,Tropea, Joseph E.,Needle, Danielle,Hilimire, Thomas A.,Schneekloth, John S.,Waugh, David S.,Pommier, Yves,Burke, Terrence R.. "Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites". . p. 3876 - 3884. Retrieved 2021/04/02.