1,2,4-Trimethylpiperazine

Base Information

• Chemical Name: 1,2,4-Trimethylpiperazine
• CAS No.: 120-85-4
• Deprecated CAS: 131022-13-4
• Molecular Formula: C7H16 N2
• Molecular Weight: 128.217
• Hs Code.: 2933599090
• European Community (EC) Number: 204-430-1
• NSC Number: 147494
• UNII: 0JY5VM09AM
• DSSTox Substance ID: DTXSID60861755
• Nikkaji Number: J265.580B
• Wikidata: Q27236878
• Mol file: 120-85-4.mol

Synonyms:1,2,4-Trimethylpiperazine;Trimethylpiperazine;Piperazine, 1,2,4-trimethyl-;120-85-4;1,2,4-TRIMETHYLDIETHYLENEDIAMINE;UNII-0JY5VM09AM;0JY5VM09AM;131065-35-5;EINECS 204-430-1;NSC 147494;NSC-147494;NSC147494;1,4-Trimethylpiperazine;CC1CN(C)CCN1C;Piperazine,2,4-trimethyl-;1,2,4-trimethyl-piperazine;SCHEMBL81182;DTXSID60861755;AKOS006238335;J265.580B;Q27236878

Chemical Property of 1,2,4-Trimethylpiperazine

Chemical Property:

• Vapor Pressure: 4.02mmHg at 25°C
• Refractive Index: 1.4433
• Boiling Point: 149.5°Cat760mmHg
• Flash Point: 31.1°C
• PSA: 6.48000
• Density: 0.863g/cm³
• LogP: 0.12790
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 92.9

Purity/Quality:

98%min ^*data from raw suppliers

1,2,4-TRIMETHYLDIETHYLENEDIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CN(CCN1C)C
• Uses: Polymerization catalyst.

Technology Process of 1,2,4-Trimethylpiperazine

There total 3 articles about 1,2,4-Trimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N`-dimethylethylenediamine (110-70-3) + 2-oxopropanal (78-98-8) → 2-methyl-N,N'-dimethylpiperazine (120-85-4)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride; In aq. phosphate buffer; at 25 ℃; for 4h; pH=7; Enzymatic reaction;

DOI:10.1021/acscatal.8b00291

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (RS)-2-methylpiperazine (109-07-9) → 2-methyl-N,N'-dimethylpiperazine (120-85-4)

Guidance literature:

With potassium carbonate; In water; for 6h; Heating;

Reference yield:

→ 2-methyl-N,N'-dimethylpiperazine (120-85-4)

Guidance literature:

2-Methylpiperazin, HCHO;

DOI:10.1016/S0040-4020(01)90752-5

upstream raw materials:

formaldehyd

(RS)-2-methylpiperazine

N,N`-dimethylethylenediamine

2-oxopropanal

Refernces

• 1、 Armarego, Wilfred L. F.,Schou, Henning,Waring, Paul. "The Absolute Configurations of (+)- and (-)-2-Methylpiperazines and their N-Methyl Derivatives.". . p. 1951 - 1966. Retrieved 2007/10/02.