3-Fluoro-benzenepropanaMine

Base Information

• Chemical Name: 3-Fluoro-benzenepropanaMine
• CAS No.: 104774-86-9
• Molecular Formula: C9H12FN
• Molecular Weight: 153.2
• Hs Code.: 2921499090
• Mol file: 104774-86-9.mol

Synonyms:3-FLUORO-BENZENEPROPANAMINE;BENZENEPROPANAMINE,3-FLUORO;

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Chemical Property of 3-Fluoro-benzenepropanaMine

Chemical Property:

• Boiling Point: 216.3±23.0 °C(Predicted)
• PKA: 10.16±0.10(Predicted)
• PSA: 26.02000
• Density: 1.044±0.06 g/cm3(Predicted)
• LogP: 2.41730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-benzenepropanaMine

There total 10 articles about 3-Fluoro-benzenepropanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(E)-3-(3-fluorophenyl)acrylamide (64379-96-0) → 3-(3-fluorophenyl)-propan-1-amine (104774-86-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 14h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.08.046

Reference yield:

3-(3-fluorophenyl)propanenitrile (25468-87-5) → 3-(3-fluorophenyl)-propan-1-amine (104774-86-9)

Guidance literature:

With ammonia; hydrogen; In methanol; ethanol; for 0.5h;

DOI:10.1021/jm401838x

Reference yield:

1-(3-azidopropyl)-3-fluorobenzene → 3-(3-fluorophenyl)-propan-1-amine (104774-86-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 12h; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.7b00830

upstream raw materials:

3-Fluorocinnamic acid

(E)-3-(3-fluorophenyl)acryloyl chloride

(E)-3-(3-fluorophenyl)acrylamide

1-(2-bromoethyl)-3-fluorobenzene

Downstream raw materials:

C₂₁H₂₂FN₃O

Refernces

• 1、 Endo, Satoshi,Xia, Shuang,Suyama, Miho,Morikawa, Yoshifumi,Oguri, Hiroaki,Hu, Dawei,Ao, Yoshinori,Takahara, Satoyuki,Horino, Yoshikazu,Hayakawa, Yoshihiro,Watanabe, Yurie,Gouda, Hiroaki,Hara, Akira,Kuwata, Kazuo,Toyooka, Naoki,Matsunaga, Toshiyuki,Ikari, Akira. "Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells". . p. 8441 - 8455. Retrieved 2017/11/03.
• 2、 -. "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition". . . Retrieved 2016/01/09.